Target Validation Information
Target ID T49072
Target Name Urotensin II receptor
Target Type
Clinical Trial
Drug Potency against Target ICI-199441 Drug Info Ki = 4000 nM [529514]
Ac-SFWKYS-NH2 Drug Info Ki < 10000 nM [530610]
SB-328872 Drug Info Ki = 110 nM [529558]
Ac-[CFWKFC]-NH2 Drug Info Ki = 17 nM [530610]
Ac-FWKY-NH2 Drug Info Ki < 10000 nM [530610]
AGTAD[CFWKYC]V Drug Info Ki = 0.19 nM [530610]
SB-436811 Drug Info Ki = 3.2 nM [530610]
PALOSURAN Drug Info IC50 = 17 nM [530610]
Ac-WKY-NH2 Drug Info Ki < 10000 nM [530610]
JNJ-28318706 Drug Info IC50 = 84 nM [530360]
References
Ref 529514Bioorg Med Chem Lett. 2008 Jul 1;18(13):3716-9. Epub 2008 May 20.Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles.
Ref 530610J Med Chem. 2010 Apr 8;53(7):2695-708.Urotensin-II receptor modulators as potential drugs.
Ref 529558Bioorg Med Chem Lett. 2008 Jul 15;18(14):3950-4. Epub 2008 Jun 10.Urotensin-II receptor antagonists: synthesis and SAR of N-cyclic azaalkyl benzamides.
Ref 530610J Med Chem. 2010 Apr 8;53(7):2695-708.Urotensin-II receptor modulators as potential drugs.
Ref 530610J Med Chem. 2010 Apr 8;53(7):2695-708.Urotensin-II receptor modulators as potential drugs.
Ref 530610J Med Chem. 2010 Apr 8;53(7):2695-708.Urotensin-II receptor modulators as potential drugs.
Ref 530610J Med Chem. 2010 Apr 8;53(7):2695-708.Urotensin-II receptor modulators as potential drugs.
Ref 530610J Med Chem. 2010 Apr 8;53(7):2695-708.Urotensin-II receptor modulators as potential drugs.
Ref 530610J Med Chem. 2010 Apr 8;53(7):2695-708.Urotensin-II receptor modulators as potential drugs.
Ref 530360J Med Chem. 2009 Dec 10;52(23):7432-45.Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits.

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