Biomarker General Infomation |
Biomarker ID |
BM003212 |
Biomarker Name |
TNF related activation protein (CD40LG) |
Disease |
Dengue |
ICD Code |
ICD-11: 1D20-1D2Z
; ICD-10: A90, R50
|
Biomarker Type |
Monitoring |
Specific Aim |
Disease severity |
Conclusion |
The observation that CD40L signaling results in enhanced DV infection of DC suggests a possible T cell-dependent mechanism for the immune-mediated enhancement of disease severity associated with some secondary dengue infections. |
UniProt ID |
|
References |
REF 1 |
CD40 ligand enhances dengue viral infection of dendritic cells: a possible mechanism for T cell-mediated immunopathology. J Immunol. 2006 Nov 1;177(9):6497-503. J Immunol. 2006 Nov 1;177(9):6497-503.
|
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