COVID-19 Drug Information
Drug General Information | Top | |||
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Drug ID |
D06VSD
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Drug Name |
Captopril
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Synonyms |
captopril; 62571-86-2; Capoten; L-Captopril; Lopirin; Captopryl; Cesplon; Captolane; Tensoprel; Dilabar; Acepress; Captoril; Tenosbon; Hypertil; Garranil; Alopresin; Lopril; Acepril; Captoprilum; Aceplus; Acediur; Tensobon; Isopresol;Apopril; Asisten; Captoprilum [INN-Latin]; SQ 14225; SQ-14225; SQ 14,225; SA 333; Captopril
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Drug Type |
Small molecular drug
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Indication | Coronavirus Disease 2019 (COVID-19) | Phase 3 | [1] | |
Other Indication | Hypertension | Approved | [2] | |
Therapeutic Class |
Antiviral Agents
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Structure |
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Download2D MOL |
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Formula |
C9H15NO3S
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Canonical SMILES |
CC(CS)C(=O)N1CCCC1C(=O)O
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InChI |
1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
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InChIKey |
FAKRSMQSSFJEIM-RQJHMYQMSA-N
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CAS Number |
CAS 62571-86-2
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:3380
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Target | Top | |||
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Target(s) | HUMAN angiotensin-converting enzyme (ACE) | Target Info | Inhibitor | [3] |
ACE inhibitor Captopril impairs the ACE/angiotensin II/angiotensin-1 receptor pathway, therefore, impairing the integrity of the ACE2/angiotensin 17/MAS (MAS-related G protein-coupled receptor). A disruption of the ACE2/angiotensin 17/MAS pathway could lead to decreased production of ACE2, decreasing chances of SARS-CoV-2 entering the cell. |
References | Top | |||
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1 | ClinicalTrials.gov (NCT04345406) Angiotensin Converting Enzyme Inhibitors in Treatment of Covid 19. U.S. National Institutes of Health. | |||
2 | FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 074532. | |||
3 | Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB. Curr Cardiol Rep. 2020 Apr 14;22(5):31. |
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