Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02XSL
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| Former ID |
DIB000235
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| Drug Name |
GlyT1 PET radiotracers
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| Synonyms |
GlyT1 PET radiotracers (schizophrenia); Glycine transporter 1 positron emission tomography radiotracers, Merck; [11C]-CMPyPB; Fluorine-18-CFpyPB; [18F]-MK-6577; GlyT1 PET radiotracers (schizophrenia), Merck & Co; 18F-CFpyPB
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| Indication | Schizophrenia [ICD-11: 6A20] | Phase 1 | [1] | |
| Company |
Merck & Co Inc
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glycine transporter GlyT-1 (SLC6A9) | Target Info | Modulator | [2] |
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | NRF2 pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Characterization of the novel GlyT1 PET tracer [18F]MK-6577 in humans. Synapse. 2015 Jan;69(1):33-40. | |||
| REF 2 | Glycine Transport Inhibitors for the Treatment of Schizophrenia. Open Med Chem J. 2010; 4: 10-19. | |||
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