Prodrug Information
| Prodrug General Information | Top | |||||
|---|---|---|---|---|---|---|
| Prodrug ID |
D5GY7P
|
|||||
| Prodrug Name |
Salsalate
|
|||||
| Synonyms |
Sasapyrine; 552-94-3; Salicylsalicylic acid; Disalicylic acid; Disalcid; 2-Carboxyphenyl salicylate; Sasapyrinum; Saloxium; Salicyloylsalicylic acid; Diacesal; Diplosal; Sasapirin; Sasapyrin; Disalyl; Nobacid; Salical; Salina; Salysal; o-Salicylsalicylic acid; Sal Ester Sal; Disalicylsaeure; Salicylic acid, salicylate; Salsalato; Salsalatum; Salflex; Salsalatum [INN-Latin]; Salicylic acid, bimolecular ester; Salicyloxysalicylic acid; Salsalato [INN-Spanish]; Salicylsalicylic acid;Disalicylic acid; Disalcid (TN); CAS-552-94-3; Sasapyrine (JAN); Salsalate [USAN:INN:BAN]; Salsalate (USP/INN)
Click to Show/Hide
|
|||||
| Indication | Osteoarthritis [ICD-11: FA00-FA05; ICD-9: 715] | Phase 4 | [1] | |||
| Rheumatoid arthritis [ICD-11: FA20; ICD-9: 729] | Phase 4 | [1] | ||||
| Activation |
Prodrug 
|
|
Parent Drug 
|
|||
| 2D MOL 3D MOL | 2D MOL 3D MOL | |||||
|
(1) Bioconversion Enzyme:
Esterase
(EC 3.1)
|
[2] | |||||
| Prodrug Strategy |
Classical prodrug strategy
[Carrier linked prodrug]
|
|||||
| Improved property |
Minimize side effect
|
[3] | ||||
| Description |
Salsalate causes less gastroduodenal damage than enteric-coated aspirin based on the results of animal models and endoscopic studies in humans.
|
[3] | ||||
| Formula |
C14H10O5
|
|||||
| Canonical SMILES |
C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O
|
|||||
| InChI |
1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
|
|||||
| InChIKey |
WVYADZUPLLSGPU-UHFFFAOYSA-N
|
|||||
| CAS Number |
CAS 552-94-3
|
|||||
| PubChem Compound ID | ||||||
| ChEBI ID |
CHEBI:9014
|
|||||
| Parent Drug General Information | Top | |||||
|---|---|---|---|---|---|---|
| Parent Drug ID |
DN8T7F
|
|||||
| Parent Drug Name |
Salicylic acid
|
|||||
| Synonyms |
2-Carboxyphenol; 2-Hydroxybenzenecarboxylate; 2-Hydroxybenzenecarboxylic acid; 2-hydroxy benzoic acid; Acido o-idrossibenzoico; Acido salicilico; Acidum salicylicum; Azurechelin; CHEMBL424; Domerine; Duofilm; Duoplant; Durasal; FEMA3985; Fostex; Ionil; Ionil plus; K 537; Keralyt; Kyselina salicylova; Occlusal; Orthohydroxybenzoic acid; Pernox; Phenol-2-carboxylate; Phenol-2-carboxylic acid; Retarder W; Rutranex; Salicyclic acid; Salicylic acid; Saligel; Salonil; Sebucare; Sebulex; Stri-Dex; TS-03583; Verrugon; hydroxy-Benzoic acid; o-Carboxyphenol; o-hydroxy benzoic acid; ortho-salicylic acid
Click to Show/Hide
|
|||||
| Formula |
C7H6O3
|
|||||
| Canonical SMILES |
C1=CC=C(C(=C1)C(=O)O)O
|
|||||
| InChI |
1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
|
|||||
| InChIKey |
YGSDEFSMJLZEOE-UHFFFAOYSA-N
|
|||||
| CAS Number |
CAS 69-72-7
|
|||||
| PubChem Compound ID | ||||||
| ChEBI ID |
CHEBI:16914
|
|||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03222206) The Comparison of Effect Between Salsalate and Placebo in Osteoarthritis With Nonalcoholic Fatty Liver Disease. U.S. National Institutes of Health. | |||||
| REF 2 | Aspirin and NSAID sensitivity. Immunol Allergy Clin North Am. 2004 Aug;24(3):491-505, vii. | |||||
| REF 3 | Gastroduodenal mucosal damage with salsalate versus aspirin: results of experimental models and endoscopic studies in humans. Semin Arthritis Rheum. 1990 Oct;20(2):121-7. | |||||
| REF 4 | Temporal relationship between use of NSAIDs, including selective COX-2 inhibitors, and cardiovascular risk. Drug Saf. 2006;29(7):621-32. | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.