Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32060 | Target Info | |||
| Target Name | 5-HT 2A receptor (HTR2A) | ||||
| Synonyms | Serotonin receptor 2A; HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT-2 | ||||
| Target Type | Successful Target | ||||
| Gene Name | HTR2A | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C | ||||
| InChI | 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 | ||||
| InChIKey | HVYWMOMLDIMFJA-DPAQBDIFSA-N | ||||
| PubChem Compound ID | 5997 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6WGT Crystal structure of HTR2A with hallucinogenic agonist | ||||||
| Method | X-ray diffraction | Resolution | 3.40 Å | Mutation | No | [1] |
| PDB Sequence |
QEKNWSALLT
81 AVVIILTIAG91 NILVIMAVSL101 EKKLQNATNY111 FLMSLAIADM121 LLGFLVMPVS 131 MLTILYGYRW141 PLPSKLCAVW151 IYLDVLFSTA161 SIMHLCAISL171 DRYVAIQNPI 181 SRFNSRTKAF193 LKIIAVWTIS203 VGISMPIPVF213 GLSKVFKEGS226 CLLADDNFVL 236 IGSFVSFFIP246 ATIMVITYFL256 TIKSLQKEAA1001 DLEDNWETLN1011 DNLKVIEKAD 1021 NAAQVKDALT1031 KMRAAALDAQ1041 KATPPKEDKS1052 PDSPEMKDFR1062 HGFDILVGQI 1072 DDAKLAKEAQ1088 AAAEQLKTTR1098 NAYIQKYLTM312 QSISNEQKAC322 KVLGIVFFLF 332 VVMWCPFFIT342 NIMAVICKES352 CNEDVIGALL362 NVFVWIGYAS372 SAVNPLVYTL 382 FNKTYRSAFS392 RYIQCQY
|
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|
|
TYR111
4.968
MET114
3.386
SER115
3.283
ILE118
3.950
LEU122
4.243
TYR153
4.706
LEU157
3.542
PHE158
4.352
PHE193
3.334
ILE196
3.831
ILE197
4.256
TRP200
3.666
VAL204
4.393
|
|||||
| PDB ID: 6WH4 Crystal structure of HTR2A with inverse agonist | ||||||
| Method | X-ray diffraction | Resolution | 3.40 Å | Mutation | No | [1] |
| PDB Sequence |
LQEKNWSALL
80 TAVVIILTIA90 GNILVIMAVS100 LEKKLQNATN110 YFLMSLAIAD120 MLLGFLVMPV 130 SMLTILYGYR140 WPLPSKLCAV150 WIYLDVLFST160 ASIMHLCAIS170 LDRYVAIQNP 180 IHHSRFNSRT190 KAFLKIIAVW200 TISVGISMPI210 PVFGLSKVFK223 EGSCLLADDN 233 FVLIGSFVSF243 FIPATIMVIT253 YFLTIKSLQK263 EAADLEDNWE1008 TLNDNLKVIE 1018 KADNAAQVKD1028 ALTKMRAAAL1038 DAQKATPPKS1052 PDSPEMKDFR1062 HGFDILVGQI 1072 DDALKLAKEA1087 QAAAEQLKTT1097 RNAYIQKYLT311 MQSISNEQKA321 CKVLGIVFFL 331 FVVMWCPFFI341 TNIMAVICKE351 SCNEDVIGAL361 LNVFVWIGYA371 SSAVNPLVYT 381 LFNKTYRSAF391 SRYIQCQY
|
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|
|
||||||
| PDB ID: 7WC8 Crystal structure of serotonin 2A receptor in complex with lumateperone | ||||||
| Method | X-ray diffraction | Resolution | 2.45 Å | Mutation | Yes | [2] |
| PDB Sequence |
HLQEKNWSAL
79 LTAVVIILTI89 AGNILVIMAV99 SLEKKLQNAT109 NYFLMSLAIA119 DMLLGFLVMP 129 VSMLTILYGY139 RWPLPSKLCA149 VWIYLDVLFS159 TAKIWHLCAI169 SLDRYVAIQN 179 PISRTKAFLK195 IIAVWTISVG205 ISMPIPVFGL215 QDDSKVFKEG225 SCLLADDNFV 235 LIGSFVSFFI245 PLTIMVITYF255 LTIKSLQKEA265 ADLEDNWETL1010 NDNLKVIEKA 1020 DNAAQVKDAL1030 TKMRAAALDA1040 DILVGQIDDA1075 LKLANEGKVK1085 EAQAAAEQLK 1095 TTINAYIQKY1105 GQSISNEQKA321 CKVLGIVFFL331 FVVMWCPFFI341 TNIMAVICKE 351 SCNEDVIGAL361 LNVFVWIGYL371 NSAVNPLVYT381 LFNKTYRSAF391 SRYIQCQYKE 401
|
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|
|
ILE93
3.806
ILE96
3.673
MET97
3.779
VAL99
3.361
SER100
3.569
LEU101
3.459
GLN106
3.005
TYR111
3.615
MET114
3.574
SER115
3.529
ILE118
3.853
MET121
3.792
LEU122
3.684
PHE158
4.503
ARG189
3.304
PHE193
3.397
ILE196
3.766
|
|||||
| PDB ID: 7WC9 Crystal structure of serotonin 2A receptor in complex with non-hallucinogenic psychedelic analog | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | Yes | [2] |
| PDB Sequence |
LQEKNWSALL
80 TAVVIILTIA90 GNILVIMAVS100 LEKKLQNATN110 YFLMSLAIAD120 MLLGFLVMPV 130 SMLTILYGYR140 WPLPSKLCAV150 WIYLDVLFST160 AKIWHLCAIS170 LDRYVAIQNP 180 SRTKAFLKII197 AVWTISVGIS207 MPIPVFGLQD217 DSKVFKEGSC227 LLADDNFVLI 237 GSFVSFFIPL247 TIMVITYFLT257 IKSLQKEAAD1002 LEDNWETLND1012 NLKVIEKADN 1022 AAQVKDALTK1032 MRAAALDADI1067 LVGQIDDALK1077 LANEGKVKEA1087 QAAAEQLKTT 1097 INAYIQKYGQ313 SISNEQKACK323 VLGIVFFLFV333 VMWCPFFITN343 IMAVICKESC 353 NEDVIGALLN363 VFVWIGYLNS373 AVNPLVYTLF383 NKTYRSAFSR393 YIQCQYKE |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:86 or .A:89 or .A:90 or .A:93 or .A:94 or .A:97 or .A:125 or .A:237 or .A:241 or .A:337 or .A:338 or .A:341 or .A:342 or .A:345 or .A:349 or .A:353 or .A:354 or .A:357 or .A:358 or .A:361 or .A:365 or .A:394 or .A:395 or .A:397 or .A:399; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE86
4.702
ILE89
4.051
ALA90
3.761
ILE93
3.716
LEU94
4.061
MET97
3.540
PHE125
4.966
ILE237
4.424
VAL241
4.121
CYS337
4.385
PRO338
3.862
ILE341
3.745
THR342
3.450
|
|||||
| PDB ID: 7WC6 Crystal structure of serotonin 2A receptor in complex with LSD | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | Yes | [2] |
| PDB Sequence |
KNWSALLTAV
83 VIILTIAGNI93 LVIMAVSLEK103 KLQNATNYFL113 MSLAIADMLL123 GFLVMPVSML 133 TILYGYRWPL143 PSKLCAVWIY153 LDVLFSTAKI163 WHLCAISLDR173 YVAIQNPSRT 190 KAFLKIIAVW200 TISVGISMPI210 PVFGLQDDSK220 VFKEGSCLLA230 DDNFVLIGSF 240 VSFFIPLTIM250 VITYFLTIKS260 LQKEAADLED1005 NWETLNDNLK1015 VIEKADNAAQ 1025 VKDALTKMRA1035 AALDADILVG1070 QIDDALKLAN1080 EGKVKEAQAA1090 AEQLKTTINA 1100 YIQKYGQSIS316 NEQKACKVLG326 IVFFLFVVMW336 CPFFITNIMA346 VICKESCNED 356 VIGALLNVFV366 WIGYLNSAVN376 PLVYTLFNKT386 YRSAFSRYIQ396 CQYKE |
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:334 or .A:337 or .A:338 or .A:341 or .A:342 or .A:345 or .A:349 or .A:353 or .A:354 or .A:357 or .A:358 or .A:361 or .A:365; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 7WC7 Crystal structure of serotonin 2A receptor in complex with lisuride | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | Yes | [2] |
| PDB Sequence |
LQEKNWSALL
80 TAVVIILTIA90 GNILVIMAVS100 LEKKLQNATN110 YFLMSLAIAD120 MLLGFLVMPV 130 SMLTILYGYR140 WPLPSKLCAV150 WIYLDVLFST160 AKIWHLCAIS170 LDRYVAIQNP 180 SRTKAFLKII197 AVWTISVGIS207 MPIPVFGLQD217 DSKVFKEGSC227 LLADDNFVLI 237 GSFVSFFIPL247 TIMVITYFLT257 IKSLQKEAAD1002 LEDNWETLND1012 NLKVIEKADN 1022 AAQVKDALTK1032 MRAAALDADI1067 LVGQIDDALK1077 LANEGKVKEA1087 QAAAEQLKTT 1097 INAYIQKYGQ313 SISNEQKACK323 VLGIVFFLFV333 VMWCPFFITN343 IMAVICKESC 353 NEDVIGALLN363 VFVWIGYLNS373 AVNPLVYTLF383 NKTYRSAFSR393 YIQCQYKE |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:337 or .A:338 or .A:341 or .A:342 or .A:345 or .A:349 or .A:353 or .A:354 or .A:357 or .A:358 or .A:361 or .A:365; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6A94 Crystal structure of 5-HT2AR in complex with zotepine | ||||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | Yes | [3] |
| PDB Sequence |
THLQEKNWSA
78 LLTAVVIILT88 IAGNILVIMA98 VSLEKKLQNA108 TNYFLMSLAI118 ADMLLGFLVM 128 PVSMLTILYG138 YRWPLPSKLC148 AVWIYLDVLF158 STAKIWHLCA168 ISLDRYVAIQ 178 NPIHHSRFNS188 RTKAFLKIIA198 VWTISVGISM208 PIPVFGLQDD218 SKVFKEGSCL 228 LADDNFVLIG238 SFVSFFIPLT248 IMVITYFLTI258 KSLQKEAADL1003 EDNWETLNDN 1013 LKVIEKADNA1023 AQVKDALTKM1033 RAAALDAGSG1043 SGDILVGQID1073 DALKLANEGK 1083 VKEAQAAAEQ1093 LKTTINAYIQ1103 KYGQSISNEQ319 KACKVLGIVF329 FLFVVMWCPF 339 FITNIMAVIC349 KESCNEDVIG359 ALLNVFVWIG369 YLSSAVNPLV379 YTLFNKTYRS 389 AFSRYIQCQY399
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:111 or .A:114 or .A:115 or .A:118 or .A:122 or .A:153 or .A:154 or .A:157 or .A:158 or .A:193 or .A:196 or .A:197 or .A:200 or .A:204; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 7VOE Crystal structure of 5-HT2AR in complex with aripiprazole | ||||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | Yes | [4] |
| PDB Sequence |
KNWSALLTAV
83 VIILTIAGNI93 LVIMAVSLEK103 KLQNATNYFL113 MSLAIADMLL123 GFLVMPVSML 133 TILYGYRWPL143 PSKLCAVWIY153 LDVLFSTAKI163 WHLCAISLDR173 YVAIQNPSRT 190 KAFLKIIAVW200 TISVGISMPI210 PVFGLQDDSK220 VFKEGSCLLA230 DDNFVLIGSF 240 VSFFIPLTIM250 VITYFLTIKS260 LQKEAADLED1005 NWETLNDNLK1015 VIEKADNAAQ 1025 VKDALTKMRA1035 AALDAGDILV1069 GQIDDALKLA1079 NEGKVKEAQA1089 AAEQLKTTIN 1099 AYIQKYGQSI315 SNEQKACKVL325 GIVFFLFVVM335 WCPFFITNIM345 AVICKESCNE 355 DVIGALLNVF365 VWIGYLNSAV375 NPLVYTLFNK385 TYRSAFSRYI395 QCQYKE |
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:89 or .A:90 or .A:93 or .A:94 or .A:96 or .A:97 or .A:100 or .A:114 or .A:118 or .A:121 or .A:122 or .A:126 or .A:154 or .A:158 or .A:338 or .A:341 or .A:342 or .A:345 or .A:349 or .A:353 or .A:354 or .A:357 or .A:358 or .A:361 or .A:365 or .A:394 or .A:395 or .A:397 or .A:399; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ILE89
4.147
ALA90
3.840
ILE93
3.857
LEU94
3.927
ILE96
3.987
MET97
3.457
SER100
3.521
MET114
4.253
ILE118
4.127
MET121
4.441
LEU122
3.615
LEU126
4.029
LEU154
4.182
PHE158
4.120
PRO338
4.604
|
|||||
| PDB ID: 6A93 Crystal structure of 5-HT2AR in complex with risperidone | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [3] |
| PDB Sequence |
THLQEKNWSA
78 LLTAVVIILT88 IAGNILVIMA98 VSLEKKLQNA108 TNYFLMSLAI118 ADMLLGFLVM 128 PVSMLTILYG138 YRWPLPSKLC148 AVWIYLDVLF158 STAKIWHLCA168 ISLDRYVAIQ 178 NPIHHSRFNS188 RTKAFLKIIA198 VWTISVGISM208 PIPVFGLQDD218 SKVFKEGSCL 228 LADDNFVLIG238 SFVSFFIPLT248 IMVITYFLTI258 KSLQKEAADL1003 EDNWETLNDN 1013 LKVIEKADNA1023 AQVKDALTKM1033 RAAALDAGSG1043 SGDILVGQID1073 DALKLANEGK 1083 VKEAQAAAEQ1093 LKTTINAYIQ1103 KYGQSISNEQ319 KACKVLGIVF329 FLFVVMWCPF 339 FITNIMAVIC349 KESCNEDVIG359 ALLNVFVWIG369 YLSSAVNPLV379 YTLFNKTYRS 389 AFSRYIQCQY399
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:111 or .A:114 or .A:115 or .A:118 or .A:122 or .A:153 or .A:154 or .A:157 or .A:158 or .A:193 or .A:196 or .A:197 or .A:200 or .A:204; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 7WC4 Crystal structure of serotonin 2A receptor in complex with serotonin | ||||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | Yes | [2] |
| PDB Sequence |
SLLHLQEKNW
76 SALLTAVVII86 LTIAGNILVI96 MAVSLEKKLQ106 NATNYFLMSL116 AIADMLLGFL 126 VMPVSMLTIL136 YGYRWPLPSK146 LCAVWIYLDV156 LFSTAKIWHL166 CAISLDRYVA 176 IQNPIHHSRF186 NSRTKAFLKI196 IAVWTISVGI206 SMPIPVFGLQ216 DDSKVFKEGS 226 CLLADDNFVL236 IGSFVSFFIP246 LTIMVITYFL256 TIKSLQKEAA1001 DLEDNWETLN 1011 DNLKVIEKAD1021 NAAQVKDALT1031 KMRAAALDAG1041 DILVGQIDDA1075 LKLANEGKVK 1085 EAQAAAEQLK1095 TTINAYIQKY1105 GQSISNEQKA321 CKVLGIVFFL331 FVVMWCPFFI 341 TNIMAVICKE351 SCNEDVIGAL361 LNVFVWIGYL371 NSAVNPLVYT381 LFNKTYRSAF 391 SRYIQCQYKE401
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:86 or .A:89 or .A:90 or .A:93 or .A:94 or .A:96 or .A:97 or .A:100 or .A:114 or .A:118 or .A:121 or .A:122 or .A:337 or .A:338 or .A:341 or .A:342 or .A:345 or .A:349 or .A:352 or .A:353 or .A:354 or .A:357 or .A:358 or .A:361 or .A:365 or .A:394 or .A:395 or .A:397 or .A:399; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ILE86
4.240
ILE89
3.864
ALA90
3.714
ILE93
3.804
LEU94
3.975
ILE96
3.998
MET97
3.397
SER100
3.627
MET114
4.176
ILE118
4.039
MET121
4.283
LEU122
3.699
CYS337
4.834
PRO338
4.010
ILE341
3.907
|
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| PDB ID: 7WC5 Crystal structure of serotonin 2A receptor in complex with psilocin | ||||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | Yes | [2] |
| PDB Sequence |
SLLHLQEKNW
76 SALLTAVVII86 LTIAGNILVI96 MAVSLEKKLQ106 NATNYFLMSL116 AIADMLLGFL 126 VMPVSMLTIL136 YGYRWPLPSK146 LCAVWIYLDV156 LFSTAKIWHL166 CAISLDRYVA 176 IQNPSRTKAF193 LKIIAVWTIS203 VGISMPIPVF213 GLQDDSKVFK223 EGSCLLADDN 233 FVLIGSFVSF243 FIPLTIMVIT253 YFLTIKSLQK263 EAADLEDNWE1008 TLNDNLKVIE 1018 KADNAAQVKD1028 ALTKMRAAAL1038 DAGDILVGQI1072 DDALKLANEG1082 KVKEAQAAAE 1092 QLKTTINAYI1102 QKYGQSISNE318 QKACKVLGIV328 FFLFVVMWCP338 FFITNIMAVI 348 CKESCNEDVI358 GALLNVFVWI368 GYLNSAVNPL378 VYTLFNKTYR388 SAFSRYIQCQ 398 YKE
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:96 or .A:100 or .A:114 or .A:118 or .A:121 or .A:122 or .A:126 or .A:189 or .A:193 or .A:338 or .A:341 or .A:342 or .A:345 or .A:349 or .A:353 or .A:354 or .A:357 or .A:358 or .A:361 or .A:365; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ILE96
4.246
SER100
3.457
MET114
3.751
ILE118
3.919
MET121
4.372
LEU122
3.482
LEU126
4.048
ARG189
4.753
PHE193
4.822
PRO338
4.381
|
|||||
| PDB ID: 7VOD Crystal structure of 5-HT2AR in complex with cariprazine | ||||||
| Method | X-ray diffraction | Resolution | 3.30 Å | Mutation | Yes | [4] |
| PDB Sequence |
KNWSALLTAV
83 VIILTIAGNI93 LVIMAVSLEK103 KLQNATNYFL113 MSLAIADMLL123 GFLVMPVSML 133 TILYGYRWPL143 PSKLCAVWIY153 LDVLFSTAKI163 WHLCAISLDR173 YVAIQNPSRT 190 KAFLKIIAVW200 TISVGISMPI210 PVFGLQDDSK220 VFKEGSCLLA230 DDNFVLIGSF 240 VSFFIPLTIM250 VITYFLTIKS260 LQKEAADLED1005 NWETLNDNLK1015 VIEKADNAAQ 1025 VKDALTKMRA1035 AALDADILVG1070 QIDDALKLAN1080 EGKVKEAQAA1090 AEQLKTTINA 1100 YIQKYGQSIS316 NEQKACKVLG326 IVFFLFVVMW336 CPFFITNIMA346 VICKESCNED 356 VIGALLNVFV366 WIGYLNSAVN376 PLVYTLFNKT386 YRSAFSRYIQ396 CQYKE |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:86 or .A:89 or .A:90 or .A:93 or .A:94 or .A:96 or .A:97 or .A:100 or .A:114 or .A:118 or .A:121 or .A:122 or .A:126 or .A:154 or .A:338 or .A:341 or .A:342 or .A:345 or .A:349 or .A:352 or .A:353 or .A:354 or .A:357 or .A:358 or .A:361 or .A:365 or .A:394 or .A:395 or .A:397 or .A:399; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE86
4.239
ILE89
4.126
ALA90
3.767
ILE93
3.584
LEU94
3.627
ILE96
4.733
MET97
3.654
SER100
3.754
MET114
4.511
ILE118
4.268
MET121
4.823
LEU122
3.746
LEU126
3.867
LEU154
4.654
PRO338
4.390
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of a Hallucinogen-Activated Gq-Coupled 5-HT 2A Serotonin Receptor. doi:10.1016/j.cell.2020.08.024. | ||||
| REF 2 | Structure-based discovery of nonhallucinogenic psychedelic analogs. Science. 2022 Jan 28;375(6579):403-411. | ||||
| REF 3 | Structures of the 5-HT(2A) receptor in complex with the antipsychotics risperidone and zotepine. Nat Struct Mol Biol. 2019 Feb;26(2):121-128. | ||||
| REF 4 | Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties. Nat Neurosci. 2022 Jan;25(1):39-49. | ||||
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