Target Validation Information
TTD ID T83797
Target Name Hepatocyte growth factor (HGF)
Type of Target
Clinical trial
Action against Disease Model Rilotumumab Drug Info Enhances temozolomide- and docetaxel-induced anti-proliferative effects in U87-MG cells in vitro; Increases docetaxel-induced apoptosis in U87-MG in vitro;Enhances temozolomide-and docetaxel-induced anti-growth effects in U87-MG xenografts [1]
REF 1 Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat Rev Drug Discov. 2008 Jun;7(6):504-16.

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