Drug General Information
Drug ID	D00MBY
Former ID	DIB014904
Drug Name	AAD-2004
Drug Type	Small molecular drug
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Phase 1	[531887]
Company	GNT Pharma Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C16H14F3NO3
Canonical SMILES	c1c(cc(c(c1)O)C(=O)O)NCCc1ccc(cc1)C(F)(F)F
PubChem Compound ID	16042343
Target and Pathway
Target(s)	Prostaglandin E synthase	Target Info	Inhibitor	[531887]
BioCyc Pathway	C20 prostanoid biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
NetPath Pathway	IL1 Signaling Pathway
	TCR Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Arachidonic acid metabolism
	Eicosanoid Synthesis
References
Ref 531887	Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61.
Ref 531887	Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61.

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