Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00MIN
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| Former ID |
DAP001247
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| Drug Name |
Propylthiouracil
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| Synonyms |
Procasil; Propacil; Propilthiouracil; Propiltiouracile; Propiltiouracilo; Propycil; Propylthiorit; Propylthiouracile; Propylthiouracilum; Propythiouracil; Prothiucil; Prothiurone; Prothycil; Prothyran; Protiural; Thiuragyl; PROPYL THIOURACIL; Propiltiouracile [DCIT]; Thyreos tat ii; Thyreostat II; HC210060; PTU (thyreostatic); Propiltiouracilo [INN-Spanish]; Propyl-Thiorist; Propyl-Thiorit; Propyl-Thyracil; Propylthiouracil (TN); Propylthiouracile [INN-French]; Propylthiouracilum [INN-Latin]; Ptu(thyreostatic); T0517-6237; Thyreostat propyl-thyracil; Propylthiouracil [INN:BAN:JAN]; Propylthiouracil (JP15/USP/INN); 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone; 2-Mercapto-4-hydroxy-6-n-propylpyrimidine; 2-Mercapto-6-propyl-4-pyrimidone; 2-Mercapto-6-propylpyrimid-4-one; 2-Mercapto-6-propylpyrimidin-4-ol; 2-Thio-4-oxo-6-propyl-1,3-pyrimidine; 2-Thio-6-propyl-1,3-pyrimidin-4-one; 4-Hydroxy-2-mercapto-6-propylpyrimidine; 4-Propyl-2-thiouracil; 6 Propyl 2 Thiouracil; 6-(n-Propyl)-2-thiouracil; 6-N-Propyl-2-thiouracil; 6-N-Propylthiouracil; 6-Prop yl-2-thiouracil; 6-Propil-tiouracile; 6-Propil-tiouracile [Italian]; 6-Propyl-2-thio-2,4(1H,3H)-pyrimidinedione; 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione; 6-Propyl-2-thiouracil; 6-Propylthiouracil; 6-Thio-4-propyluracil; 6-n-PROPYL-2-MERCAPTO-4-HYDROXYPYRIMIDINE; 6-propyl-2 thiouracil; 6-propyl-2-sulfanylidene-1H-pyrimidin-4-one; 6-propyl-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one; 6-propyl-2-thiopyrimidine-2,4(1H,3H)-dione; 6-propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Antithyroid Agents
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| Structure |
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Download2D MOL |
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| Formula |
C7H10N2OS
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| InChI |
InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
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| InChIKey |
KNAHARQHSZJURB-UHFFFAOYSA-N
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| CAS Number |
CAS 51-52-5
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9772, 72466, 113849, 630519, 855783, 3133458, 5371778, 6405436, 7847628, 7980419, 8147858, 8149507, 9268267, 10321756, 10524876, 11112111, 11335443, 11360682, 11363770, 11366332, 11368894, 11372721, 11374142, 11377056, 11461654, 11466522, 11467642, 11485099, 11486044, 11489118, 11491546, 11492307, 11494690, 14772576, 17389748, 22389304, 24870375, 24898446, 25183806, 26611899, 26679369, 26747269, 26747270, 26751509, 46505181, 47365078, 47365079, 47885302, 47885303, 47959626
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| ChEBI ID |
ChEBI:8502
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| SuperDrug ATC ID |
H03BA02
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| SuperDrug CAS ID |
cas=000051525
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| Target and Pathway | |||||
| Target(s) | Type I iodothyronine deiodinase | Target Info | Inhibitor | [536479] | |
| Thyroid peroxidase | Target Info | Inhibitor | [536420] | ||
| NetPath Pathway | TSH Signaling Pathway | ||||
| PathWhiz Pathway | Thyroid hormone synthesis | ||||
| Reactome | Thyroxine biosynthesis | ||||
| References | |||||
| Ref 538392 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 006188. | ||||
| Ref 541761 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6650). | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| Ref 536420 | Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions. Bioinorg Chem Appl. 2006:23214. Epub 2006 Nov 12. | ||||
| Ref 536479 | Type 1 iodothyronine deiodinase is the major source of circulating T3 in hyperthyroidism: implications for therapy. Nat Clin Pract Endocrinol Metab. 2007 Nov;3(11):740-1. Epub 2007 Aug 21. | ||||
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