Drug Information

Drug General Information
Drug ID
D00NNC
Former ID
DAP000827
Drug Name
Etidronic acid
Synonyms
EHDP; Etidronate; Etidronsaeure; HEDP; Osteoscan; Acetodiphosphonic acid; Acide etidronique; Acido etidronico; Acidumetidronicum; Didronel IV; Etidronic acid monohydrate; Hydroxyethanediphosphonic acid; MPI Stannous Diphosphonate; Oxyethylidenediphosphonic acid; Turpinal SL; Cintichem Technetium 99m Hedspa; Dequest2010; Dequest 2015; Dequest Z 010; Ferrofos 510; RP 61; Acide etidronique [INN-French]; Acido etidronico [INN-Spanish]; Acidum etidronicum [INN-Latin]; Diphosphonate (base); Etidronic acid (USAN/INN); Etidronic acid [USAN:INN:BAN]; Hydroxyethane-1,1-diphosphonic acid; Ethane-1-hydroxy-1,1-bisphosphonate; Ethane-1-hydroxy-1,1-bisphosphonic acid; Ethane-1-hydroxy-1,1-diphosphonate; Ethane-1-hydroxy-1,1-diphosphonic acid; Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester; (1-Hydroxyethylene)diphosphonic acid; (1-Hydroxyethylidene)bis(phosphonic acid); (1-Hydroxyethylidene)bisphosphonic acid; (1-Hydroxyethylidene)diphoshonic acid; (1-Hydroxyethylidene)diphosphonic acid; (1-hydroxy-1-phosphonoethyl)phosphonic acid; (1-hydroxyethane-1,1-diyl)bis(phosphonic acid); (Hydroxyethylidene)diphosphonic acid; 1,1,1-Ethanetriol diphosphonate; 1-HYDROXY-1,1-DIPHOSPHONOETHANE; 1-Hydroxyethane-1,1,-diphosphonic acid; 1-Hydroxyethane-1,1-bisphosphonic acid; 1-Hydroxyethane-1,1-diphosphonate; 1-Hydroxyethane-1,1-diphosphonic acid; 1-Hydroxyethanediphosphonic acid; 1-Hydroxyethylidene 1,1-diphosphonic acid; 1-Hydroxyethylidene-1,1-biphosphonate; 1-Hydroxyethylidene-1,1-bisphosphonate; 1-Hydroxyethylidene-1,1-diphosphonic acid; 1-Hydroxyethylidenediphosphonic acid; 1000SL
Drug Type
Small molecular drug
Indication Paget's disease [ICD9: 731; ICD10:M88] Approved [542195], [550686]
Therapeutic Class
Bone Density Conservation Agents
Structure
Download
2D MOL

3D MOL
Formula
C2H8O7P2
InChI
InChI=1S/C2H8O7P2/c1-2(3,10(4,5)6)11(7,8)9/h3H,1H3,(H2,4,5,6)(H2,7,8,9)
InChIKey
DBVJJBKOTRCVKF-UHFFFAOYSA-N
CAS Number
CAS 7414-83-7
PubChem Compound ID
3305
PubChem Substance ID
9938, 132168, 626344, 5268197, 7849432, 8152103, 11466891, 11468011, 11486562, 14797598, 24878684, 24895766, 29215269, 29222442, 46507694, 47365358, 47515472, 47959932, 48110605, 48415987, 48417898, 50007630, 50587317, 53789362, 57321717, 57651468, 57654267, 81093251, 85175936, 87570971, 93576729, 93576926, 98461899, 103228758, 104009084, 104303122, 111978152, 117823194, 124892103, 124892104, 125346884, 126655223, 126674414, 126730500, 127711966, 131349600, 131806666, 134338107, 134340010, 134983248
SuperDrug ATC ID
M05BA01
Target and Pathway
Target(s) Receptor-type protein-tyrosine phosphatase S Target Info Inhibitor [538010]
Reactome ECM proteoglycans
WikiPathways Extracellular matrix organization
References
Ref 542195(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7184).
Ref 550686Drug information of Didronel, 2008. eduDrugs.
Ref 538010Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. J Bone Miner Res. 1996 Apr;11(4):535-43.

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