Drug Information

Drug General Information
Drug ID
D00PEH
Former ID
DCL000792
Drug Name
Eltrombopag
Synonyms
Promacta; Eltrombopag [INN]; SB 497115; SB497115; SB-497115; [1,1'-Biphenyl]-3-carboxylic acid, 3'-[(2Z)-[1-(3,4-dime; Thylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-(9CI); (E)-3\'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2\'-hydroxybiphenyl-3-carboxylic acid
Drug Type
Small molecular drug
Indication Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10:D69.6, P61.0] Approved [529941], [541996]
Idiopathic thrombocytopenic purpura [ICD9: 287.31; ICD10:D69.3] Phase 3 [536737], [541996]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C25H22N4O4
InChI
InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-
InChIKey
XDXWLKQMMKQXPV-QYQHSDTDSA-N
CAS Number
CAS 443130-00-5
PubChem Compound ID
9846180
PubChem Substance ID
14808156, 29195841, 34806226, 44944248, 57373520, 76939526, 85853055, 93581192, 99006117, 123051088, 124772070, 126667018, 126731321, 135196778, 136367954, 136376451, 137206169, 137617354, 143498067, 144115937, 152059665, 152236438, 152344172, 162037592, 162201758, 162262104, 174476496, 175266113, 175427059, 176485025, 180371853, 188899541, 210275214, 210280853, 223671302, 226526630, 226566011, 226566012, 242060270, 242084108, 249823455, 250203595, 251894921, 251971165, 252058465, 252215343
Target and Pathway
Target(s) Thrombopoietin Receptor Target Info Agonist [536737]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
WikiPathways Platelet Aggregation (Plug Formation)
References
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
Ref 536737Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
Ref 541996(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6961).
Ref 536737Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.

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