Drug General Information
Drug ID
D00YNY
Former ID
DIB000480
Drug Name
VPC-94075
Synonyms
Sphingosine kinase inhibitor (vascular disease); VPC-94075; Sphingosine kinase inhibitor (vascular disease), University of Virgina
Drug Type
Small molecular drug
Indication Vascular disease [ICD9: 325, 430-459; ICD10:G45-G46, I60-I95] Investigative [541297]
Company
University of Virginia
Structure
Download
2D MOL

3D MOL

Formula
C15H11ClN2OS
InChI
InChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)
InChIKey
ZFGXZJKLOFCECI-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Sphingosine kinase Target Info Inhibitor [543575]
BioCyc Pathway Sphingosine and sphingosine-1-phosphate metabolism
KEGG Pathway Sphingolipid metabolism
Metabolic pathways
Calcium signaling pathway
Sphingolipid signaling pathway
VEGF signaling pathway
Fc gamma R-mediated phagocytosis
Tuberculosis
NetPath Pathway TCR Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
Beta3 integrin cell surface interactions
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome Sphingolipid de novo biosynthesis
VEGFR2 mediated cell proliferation
WikiPathways Signal Transduction of S1P Receptor
Protein folding
Sphingolipid Metabolism
References
Ref 541297(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6041).
Ref 543575(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2204).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.