Drug Information

Drug General Information
Drug ID
D00YUB
Former ID
DIB003205
Drug Name
NT-3
Synonyms
Neurotrophin-3; NT-3, Amgen-Regeneron Partners; NT-3, Amgen/ Regeneron; Neurotrophin-3, Amgen-Regeneron Partners; Neurotrophin-3, Amgen/ Regeneron
Indication Constipation [ICD9: 564; ICD10:K59.0] Discontinued in Phase 2 [468135], [545887]
Company
Takeda Pharmaceutical Co Ltd
CAS Number
CAS 130939-66-1
Target and Pathway
Target(s) Neurotrophin-3 Target Info Modulator [527621]
KEGG Pathway MAPK signaling pathway
Neurotrophin signaling pathway
Pathway Interaction Database SHP2 signaling
p75(NTR)-mediated signaling
Neurotrophic factor-mediated Trk receptor signaling
Trk receptor signaling mediated by the MAPK pathway
WikiPathways BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
References
Ref 468135(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5033).
Ref 545887Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005227)
Ref 527621NT-3. Takeda/Regeneron/Amgen. IDrugs. 2001 Jul;4(7):820-4.

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