Drug Information

Drug General Information
Drug ID
D00YWL
Former ID
DIB001371
Drug Name
BMS-936557
Synonyms
MDX-1100; Anti-CXCL10 antibody (iv, ulcerative colitis/ rheumatoid arthritis/ inflammation), Medarex/BMS; Anti-IP-10 antibody (iv, ulcerative colitis/ rheumatoid arthritis/ inflammation), Bristol-Myers Squibb/Medarex
Drug Type
Antibody
Indication Immune disorder [ICD10:D80-D89] Phase 2 [523682]
Company
Medarex Inc
Target and Pathway
Target(s) Small inducible cytokine B10 Target Info [532252]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
TNF signaling pathway
Influenza A
NetPath Pathway IL-7 Signaling Pathway
TSLP Signaling Pathway
TNFalpha Signaling Pathway
TWEAK Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database CXCR3-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways Toll-like receptor signaling pathway
Type II interferon signaling (IFNG)
Spinal Cord Injury
GPCR ligand binding
GPCR downstream signaling
Regulation of toll-like receptor signaling pathway
References
Ref 523682ClinicalTrials.gov (NCT01466374) Induction and Maintenance Study of BMS-936557 in Patients With Moderate to Severely Active Crohn's Disease. U.S. National Institutes of Health.
Ref 532252Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study. Gut. 2014 Mar;63(3):442-50.

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