TTD | Drug: D01DAQ

Drug General Information
Drug ID	D01DAQ
Former ID	DNC010617
Drug Name	5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530697]
Structure		Download 2D MOL 3D MOL
Formula	C8H8FN5O2
Canonical SMILES	C1=CN(C(=N1)N)CC2=C(C(=O)NC(=O)N2)F
InChI	1S/C8H8FN5O2/c9-5-4(12-8(16)13-6(5)15)3-14-2-1-11-7(14)10/h1-2H,3H2,(H2,10,11)(H2,12,13,15,16)
InChIKey	SFEMKOUUPCFITA-UHFFFAOYSA-N
PubChem Compound ID	44632008
Target and Pathway
Target(s)	Thymidine phosphorylase	Target Info	Inhibitor	[530697]
BioCyc Pathway	Pyrimidine deoxyribonucleosides degradation
KEGG Pathway	Pyrimidine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways
	Bladder cancer
NetPath Pathway	TSH Signaling Pathway
PathWhiz Pathway	Pyrimidine Metabolism
WikiPathways	Bladder Cancer
	Metabolism of nucleotides
	Fluoropyrimidine Activity
References
Ref 530697	Bioorg Med Chem Lett. 2010 Mar 1;20(5):1648-51. Epub 2010 Jan 21.The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism.
Ref 530697	Bioorg Med Chem Lett. 2010 Mar 1;20(5):1648-51. Epub 2010 Jan 21.The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism.

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Drug Information