Drug Information

Drug General Information
Drug ID
D01FLN
Former ID
DIB007368
Drug Name
LX-2932
Synonyms
S1P lyase inhibitor (autoimmune diseases), Lexicon; Sphingosine-1-phosphate lyase inhibitor (autoimmune diseases), Lexicon
Drug Type
Small molecular drug
Indication Autoimmune diabetes [ICD10:E08-E13] Terminated [548103]
Company
Lexicon Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C10H14ClN3O5
Canonical SMILES
c1(nc([nH]c1)c1nocc1)[C@H]([C@H](O)[C@@H](CO)O)O
PubChem Compound ID
49858086
Target and Pathway
Target(s) Sphingosine 1 phosphate lyase 1 Target Info Inhibitor [531269]
KEGG Pathway Sphingolipid metabolism
Metabolic pathways
Sphingolipid signaling pathway
Pathway Interaction Database Sphingosine 1-phosphate (S1P) pathway
PathWhiz Pathway Sphingolipid Metabolism
Reactome Sphingolipid de novo biosynthesis
WikiPathways Sphingolipid metabolism
References
Ref 548103Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021957)
Ref 531269Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932). J Med Chem. 2010 Dec 23;53(24):8650-62.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.