Drug General Information
Drug ID	D01ICY
Former ID	DIB008664
Drug Name	AVE-0657
Synonyms	IDDBCP219683
Indication	Cheyne-stokes respiration [ICD10:R06.3]		Phase 2	[522222]
Company	Sanofi
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(nc2c([nH]1)cccc2)Nc1c(scc1C)Cl.Cl
Target and Pathway
Target(s)	Sodium/hydrogen exchanger 3	Target Info	Inhibitor	[532610]
KEGG Pathway	Proximal tubule bicarbonate reclamation
	Protein digestion and absorption
	Bile secretion
	Mineral absorption
Pathway Interaction Database	Endothelins
	RhoA signaling pathway
WikiPathways	SIDS Susceptibility Pathways
References
Ref 522222	ClinicalTrials.gov (NCT00614250) Evaluation of the Effect of AVE0657 on Obstructive Sleep Apnea. U.S. National Institutes of Health.
Ref 532610	Inhibition of central Na(+)/H(+) exchanger type 3 can alleviate sleep apnea in Sprague-Dawley rats. Chin Med J (Engl). 2014;127(1):48-53.

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