Drug Information

Drug General Information
Drug ID
D01PZD
Former ID
DCL000629
Drug Name
Romiplostim
Drug Type
Small molecular drug
Indication Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10:D69.6, P61.0] Approved [529941], [542005]
Chemotherapy-induced thrombocytopenia; Myelodysplastic syndromes [ICD9: 238.7, 287.3, 287.4, 287.5; ICD10:D46, D69.6, P61.0] Phase 2 [536737], [542005]
Company
Amgen
Structure
Download
2D MOL

3D MOL
Formula
C15H14N2O
Canonical SMILES
CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C
InChI
1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
InChIKey
WUWDLXZGHZSWQZ-WQLSENKSSA-N
CAS Number
CAS 267639-76-9
PubChem Compound ID
5329098
PubChem Substance ID
525180, 8034458, 10318718, 11061325, 12015099, 14847387, 17405666, 24278606, 26759729, 26759733, 39301723, 47207480, 47348964, 47572946, 49674962, 49984916, 50076383, 50107014, 50107015, 50107016, 53778216, 53789746, 56312333, 56312335, 56312337, 56312516, 56312518, 56312520, 56320689, 56322916, 57361292, 74446362, 85789116, 90341564, 91722386, 92303403, 99302833, 103175684, 113911626, 121362026, 121493282, 124750244, 124800944, 124891688, 134339165, 134339435, 134340578, 134341737, 135079569, 135141433
SuperDrug ATC ID
B02BX04
Target and Pathway
Target(s) Thrombopoietin Receptor Target Info Modulator [529941]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
WikiPathways Platelet Aggregation (Plug Formation)
References
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
Ref 536737Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
Ref 542005(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6974).
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.

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