Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01UDV
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| Former ID |
DNC000813
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| Drug Name |
ISIS 5132
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| Drug Type |
Small molecular drug
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| Indication | Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] | Phase 2 | [525152] | ||
| Formula |
C193H247N68O102P19S19
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| Canonical SMILES |
CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=S)(O)OC3CC(OC3COP(=S)(<br />O)OC4CC(OC4COP(=S)(O)OC5CC(OC5COP(=S)(O)OC6CC(OC6COP(=S<br />)(O)OC7CC(OC7COP(=S)(O)OC8CC(OC8COP(=S)(O)OC9CC(OC9COP(<br />=S)(O)OC1CC(OC1COP(=S)(O)OC1CC(OC1COP(=O)(OC1CC(OC1COP(<br />=S)(O)OC1CC(OC1COP(=S)(O)OC1CC(OC1COP(=S)(O)OC1CC(OC1CO<br />P(=S)(O)OC1CC(OC1COP(=S)(O)OC1CC(OC1COP(=S)(O)OC1CC(OC1<br />COP(=S)(O)OC1CC(OC1COP(=S)(O)OC1CC(OC1COP(=S)(O)OC1CC(O<br />C1CO)N1C=C(C(=O)NC1=O)C)N1C=CC(=NC1=O)N)N1C=CC(=NC1=O)N<br />)N1C=CC(=NC1=O)N)N1C=NC2=C1N=C(NC2=O)N)N1C=CC(=NC1=O)N)<br />N1C=CC(=NC1=O)N)N1C=C(C(=O)NC1=O)C)N1C=NC2=C1N=C(NC2=O)<br />N)N1C=C(C(=O)NC1=O)C)S)N1C=NC2=C1N=C(NC2=O)N)N1C=NC2=C1<br />N=CN=C2N)N1C=CC(=NC1=O)N)N1C=NC2=C1N=CN=C2N)N1C=C(C(=O)<br />NC1=O)C)N1C=NC2=C1N=C(NC2=O)N)N1C=CC(=NC1=O)N)N1C=NC2=C<br />1N=CN=C2N)N1C=C(C(=O)NC1=O)C)O
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| InChI |
1S/C193H247N68O102P19S19/c1-77-41-249(188(281)236-167(77)264)130-21-83(263)104(326-130)48-306-364(287,383)353-92-30-139(251-43-79(3)169(266)238-190(251)283)334-112(92)56-315-379(302,398)358-97-35-144(256-71-215-151-158(202)209-68-212-161(151)256)338-116(97)60-319-371(294,390)351-91-29-137(248-20-13-129(200)227-187(248)280)333-111(91)55-313-378(301,397)361-100-38-147(259-74-218-154-164(259)229-178(205)233-174(154)271)342-120(100)64-322-374(297,393)355-94-32-141(253-45-81(5)171(268)240-192(253)285)336-114(94)58-316-380(303,399)359-98-36-145(257-72-216-152-159(203)210-69-213-162(152)257)339-117(98)61-318-370(293,389)350-90-28-136(247-19-12-128(199)226-186(247)279)331-109(90)53-311-376(299,395)357-96-34-143(255-70-214-150-157(201)208-67-211-160(150)255)340-118(96)62-320-382(305,401)363-102-40-149(261-76-220-156-166(261)231-180(207)235-176(156)273)344-122(102)66-324-375(298,394)356-95-33-142(254-46-82(6)172(269)241-193(254)286)337-115(95)59-317-381(304,400)362-101-39-148(260-75-219-155-165(260)230-179(206)234-175(155)272)343-121(101)65-323-373(296,392)354-93-31-140(252-44-80(4)170(267)239-191(252)284)335-113(93)57-314-369(292,388)349-88-26-134(245-17-10-126(197)224-184(245)277)329-107(88)51-309-368(291,387)348-87-25-133(244-16-9-125(196)223-183(244)276)332-110(87)54-312-377(300,396)360-99-37-146(258-73-217-153-163(258)228-177(204)232-173(153)270)341-119(99)63-321-372(295,391)352-89-27-135(246-18-11-127(198)225-185(246)278)330-108(89)52-310-367(290,386)347-86-24-132(243-15-8-124(195)222-182(243)275)328-106(86)50-308-366(289,385)346-85-23-131(242-14-7-123(194)221-181(242)274)327-105(85)49-307-365(288,384)345-84-22-138(325-103(84)47-262)250-42-78(2)168(265)237-189(250)282/h7-20,41-46,67-76,83-122,130-149,262-263H,21-40,47-66H2,1-6H3,(H,287,383)(H,288,384)(H,289,385)(H,290,386)(H,291,387)(H,292,388)(H,293,389)(H,294,390)(H,295,391)(H,296,392)(H,297,393)(H,298,394)(H,299,395)(H,300,396)(H,301,397)(H,302,398)(H,303,399)(H,304,400)(H,305,401)(H2,194,221,274)(H2,195,222,275)(H2,196,223,276)(H2,197,224,277)(H2,198,225,278)(H2,199,226,279)(H2,200,227,280)(H2,201,208,211)(H2,202,209,212)(H2,203,210,213)(H,236,264,281)(H,237,265,282)(H,238,266,283)(H,239,267,284)(H,240,268,285)(H,241,269,286)(H3,204,228,232,270)(H3,205,229,233,271)(H3,206,230,234,272)(H3,207,231,235,273)
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| InChIKey |
OMEUGRCNAZNQLN-UHFFFAOYSA-N
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| CAS Number |
CAS 177075-18-2
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Proto-oncogene c-RAF | Target Info | Modulator | ||
| References | |||||
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