Drug Information

Drug General Information
Drug ID
D02HDG
Former ID
DIB009934
Drug Name
AQX-1125
Synonyms
AQX-108; AQX-131; AQX-132; AQX-133; AQX-134; AQX-135; AQX-140; AQX-150; SHIP agonists (cancer/inflammation), Aquinox
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Phase 2 [525040]
Company
Aquinox Pharmaceuticals Inc
Structure
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2D MOL

3D MOL
Target and Pathway
Target(s) SH2 domain inositol phosphatase Target Info Agonist [532100]
BioCyc Pathway 3-phosphoinositide degradation
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
Superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
Superpathway of inositol phosphate compounds
D-myo-inositol (1,3,4)-trisphosphate biosynthesis
KEGG Pathway Inositol phosphate metabolism
Phosphatidylinositol signaling system
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
PathWhiz Pathway Phosphatidylinositol Phosphate Metabolism
Fc Epsilon Receptor I Signaling in Mast Cells
Reactome PECAM1 interactions
Interleukin receptor SHC signaling
WikiPathways EGF/EGFR Signaling Pathway
IL-4 Signaling Pathway
Kit receptor signaling pathway
IL-3 Signaling Pathway
Interleukin-2 signaling
B Cell Receptor Signaling Pathway
TCR signaling
Interleukin-3, 5 and GM-CSF signaling
Cell surface interactions at the vascular wall
References
Ref 525040ClinicalTrials.gov (NCT02324972) Pilot Efficacy and Safety Study of AQX-1125 in Atopic Dermatitis. U.S. National Institutes of Health.
Ref 532100Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo. Br J Pharmacol. 2013 Mar;168(6):1519-29.

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