Drug Information

Drug General Information
Drug ID
D02QBT
Former ID
DIB001603
Drug Name
AZETIRELIN
Synonyms
Azetirelin < Rec INN >; YM-14673 (dihydrate); Nalpha-[(S)-2-Azetidinone-4-carbonyl]-L-histidyl-L-prolinamide
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 3 [544285]
Structure
Download
2D MOL

3D MOL
Formula
C15H20N6O4
Canonical SMILES
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]3C<br />C(=O)N3
InChIKey
WBGUMUGCONUXFK-DCAQKATOSA-N
CAS Number
CAS 95729-65-0
PubChem Compound ID
65841
Target and Pathway
Target(s) Thyrotropin-releasing hormone receptor Target Info Modulator [531635], [533643]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Thyrotropin-releasing hormone receptor signaling pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 544285Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 March; 69(1): 21-31.
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 533643Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. II. In situ and in vitro absorption characteristics of azetirelin from the rat intestine. Biol Pharm Bull. 1995 Jul;18(7):976-9.

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