Drug Information

Drug General Information
Drug ID
D02XSL
Former ID
DIB000235
Drug Name
GlyT1 PET radiotracers
Synonyms
GlyT1 PET radiotracers (schizophrenia); Glycine transporter 1 positron emission tomography radiotracers, Merck; [11C]-CMPyPB; Fluorine-18-CFpyPB; [18F]-MK-6577; GlyT1 PET radiotracers (schizophrenia), Merck & Co; 18F-CFpyPB
Indication Schizophrenia [ICD9: 295; ICD10:F20] Phase 1 [532944]
Company
Merck & Co Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
C1CN(CCC1(CNC(=O)c1ccc(cc1Cl)Cl)c1cccc(n1)[18F])S(=O)(=<br />O)CCC
Target and Pathway
Target(s) Sodium- and chloride-dependent glycine transporter 1 Target Info Modulator [544160]
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways NRF2 pathway
References
Ref 532944Characterization of the novel GlyT1 PET tracer [18F]MK-6577 in humans. Synapse. 2015 Jan;69(1):33-40.
Ref 544160Glycine Transport Inhibitors for the Treatment of Schizophrenia. Open Med Chem J. 2010; 4: 10-19.

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