Drug General Information
Drug ID	D02YQJ
Former ID	DIB000649
Drug Name	B-5354a
Synonyms	B-5354a; B-5354b; B-5354c; Sphingosine kinase inhibitors, Sankyo
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Terminated	[525909]
Company	Sankyo Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(c1cc(c(cc1)N)O)OCCCC/C=C/CCCCCC
Target and Pathway
Target(s)	Sphingosine kinase	Target Info	Inhibitor	[525910]
BioCyc Pathway	Sphingosine and sphingosine-1-phosphate metabolism
KEGG Pathway	Sphingolipid metabolism
	Metabolic pathways
	Calcium signaling pathway
	Sphingolipid signaling pathway
	VEGF signaling pathway
	Fc gamma R-mediated phagocytosis
	Tuberculosis
NetPath Pathway	TCR Signaling Pathway
	TNFalpha Signaling Pathway
PANTHER Pathway	Angiogenesis
	VEGF signaling pathway
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cells
	Beta3 integrin cell surface interactions
	S1P1 pathway
	Sphingosine 1-phosphate (S1P) pathway
	PDGFR-beta signaling pathway
Reactome	Sphingolipid de novo biosynthesis
	VEGFR2 mediated cell proliferation
WikiPathways	Signal Transduction of S1P Receptor
	Protein folding
	Sphingolipid Metabolism
References
Ref 525909	B-535a, b and c, new sphingosine kinase inhibitors, produced by a marine bacterium; taxonomy, fermentation, isolation, physico-chemical properties and structure determination. J Antibiot (Tokyo). 2000 Aug;53(8):753-8.
Ref 525910	Characterization of B-5354c, a new sphingosine kinase inhibitor, produced by a marine bacterium. J Antibiot (Tokyo). 2000 Aug;53(8):759-64.

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