Drug General Information
Drug ID	D03AGV
Former ID	DNC012173
Drug Name	N-(3-Methanesulfonyl-4-methyl-benzoyl)-guanidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534413]
Structure		Download 2D MOL 3D MOL
Formula	C10H13N3O3S
Canonical SMILES	CC1=C(C=C(C=C1)C(=O)N=C(N)N)S(=O)(=O)C
InChI	1S/C10H13N3O3S/c1-6-3-4-7(9(14)13-10(11)12)5-8(6)17(2,15)16/h3-5H,1-2H3,(H4,11,12,13,14)
InChIKey	LHXXNXYVTIIVIY-UHFFFAOYSA-N
PubChem Compound ID	19096138
Target and Pathway
Target(s)	Sodium/hydrogen exchanger 3	Target Info	Inhibitor	[534413]
	Sodium/hydrogen exchanger 1	Target Info	Inhibitor	[534413]
KEGG Pathway	Proximal tubule bicarbonate reclamation
	Protein digestion and absorption
	Bile secretion
	Mineral absorptionhsa04024:cAMP signaling pathway
	Cardiac muscle contraction
	Adrenergic signaling in cardiomyocytes
	Regulation of actin cytoskeleton
	Thyroid hormone signaling pathway
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretion
	Proteoglycans in cancer
Pathway Interaction Database	Endothelins
	RhoA signaling pathwayendothelinpathway:Endothelins
	RhoA signaling pathway
	ErbB1 downstream signaling
	Signaling mediated by p38-alpha and p38-beta
Reactome	Hyaluronan uptake and degradation
WikiPathways	SIDS Susceptibility PathwaysWP51:Regulation of Actin Cytoskeleton
	G Protein Signaling Pathways
	Glycosaminoglycan metabolism
	Osteoclast Signaling
References
Ref 534413	J Med Chem. 1997 Jun 20;40(13):2017-34.(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.
Ref 534413	J Med Chem. 1997 Jun 20;40(13):2017-34.(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.

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