Drug General Information
Drug ID	D03BHO
Former ID	DIB003427
Drug Name	JTP-2942
Drug Type	Small molecular drug
Indication	Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3]		Discontinued in Phase 2	[545198]
Company	Japan Tobacco Inc
Structure		Download 2D MOL 3D MOL
Formula	C18H25N5O4
Canonical SMILES	N1(C(=O)[C@@H](NC(=O)[C@@H]2[C@@H](CC(=O)C2)C)Cc2nc[nH]<br />c2)[C@H](C(=O)N)CCC1
CAS Number	CAS 148152-77-6
PubChem Compound ID	127299
Target and Pathway
Target(s)	Thyrotropin-releasing hormone receptor	Target Info	Modulator	[533738]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Thyrotropin-releasing hormone receptor signaling pathway
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545198	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002435)
Ref 533738	Effect of JTP-2942, a novel thyrotropin-releasing hormone analogue, on pentobarbital-induced anesthesia in rats. Eur J Pharmacol. 1995 Mar 24;276(1-2):177-82.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.