Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03FPA
|
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| Former ID |
DIB012669
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| Drug Name |
APP-018
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| Synonyms |
D-4F; Apolipoprotein A1 mimetic (atherosclerosis), Bruin Pharma; Apolipoprotein A1 mimetic (atherosclerosis),Novartis
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| Indication | Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] | Discontinued in Phase 1 | [548120] | ||
| Company |
Bruin Pharma Inc
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| Structure |
|
Download2D MOL |
|||
| Formula |
C114H156N24O28
|
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| Canonical SMILES |
c1(c[nH]c2c1cccc2)C[C@@H](NC(=O)[C@H](NC(=O)C)CC(=O)O)C<br />(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O<br />)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[<br />C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@<br />H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N)Cc1ccc<br />cc1)C)CCC(=O)O)CCCCN)Cc1ccccc1)CCCCN)CCC(=O)O)C)C(C)C)C<br />CCCN)CC(=O)O)Cc1ccc(cc1)O)Cc1ccccc1)C)CCCCN)Cc1ccccc1
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Apolipoprotein A-I | Target Info | Modulator | [544167] | |
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| TNFalpha Signaling Pathway | |||||
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks | ||||
| Reactome | Platelet degranulation | ||||
| ABC transporters in lipid homeostasis | |||||
| Chylomicron-mediated lipid transport | |||||
| HDL-mediated lipid transport | |||||
| PPARA activates gene expression | |||||
| Scavenging of heme from plasma | |||||
| Scavenging by Class B Receptors | |||||
| Scavenging by Class A Receptors | |||||
| Retinoid metabolism and transport | |||||
| Amyloid formation | |||||
| WikiPathways | Statin Pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| PPAR Alpha Pathway | |||||
| Human Complement System | |||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| Binding and Uptake of Ligands by Scavenger Receptors | |||||
| Visual phototransduction | |||||
| Lipid digestion, mobilization, and transport | |||||
| ABC-family proteins mediated transport | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
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