Drug Information

Drug General Information
Drug ID
D03KVC
Former ID
DNC001011
Drug Name
NFPS
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467860]
Formula
C24H24FNO3
InChI
InChI=1S/C24H24FNO3/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18/h2-14,23H,15-17H2,1H3,(H,27,28)
InChIKey
FDORQEIHOKEJNX-UHFFFAOYSA-N
CAS Number
CAS 128517-07-7
PubChem Compound ID
5311283
PubChem Substance ID
7979967, 11056407, 15425749, 39340982, 57359418, 78757039, 103192822, 104018165, 114155736, 135698632, 142331555, 163123295, 178101337, 178101338, 196376338, 204363644, 219812561, 226751760, 241080701, 243101135, 249617695, 252126260, 252156790, 252229004, 252268305
Target and Pathway
Target(s) Sodium- and chloride-dependent glycine transporter 1 Target Info Blocker [535780]
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways NRF2 pathway
References
Ref 467860(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4620).
Ref 535780The glycine transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J Neurosci. 2003 Aug 20;23(20):7586-91.

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