Drug Information

Drug General Information
Drug ID
D03PYO
Former ID
DIB011187
Drug Name
PROMACTA
Synonyms
Thrombopoietin receptor agonists (thrombocytopenia); Thrombopoietin receptor agonists (thrombocytopenia), GNF; Thrombopoietin receptor agonists (thrombocytopenia), Genomics Institute of the Novartis Research Foundation
Drug Type
Small molecular drug
Indication Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10:D69.6, P61.0] Approved [543468]
Company
Novartis Institute of Functional Genomics
Structure
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2D MOL

3D MOL
Formula
C27H29N5O5
Canonical SMILES
c1c(ccc(c1)c1c(c2c(cc1)c1c([nH]2)c2c(C1)cc(cc2)NC(=O)C)<br />F)CCCC
PubChem Compound ID
71719015
Target and Pathway
Target(s) Thrombopoietin Receptor Target Info Agonist [543468]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
WikiPathways Platelet Aggregation (Plug Formation)
References
Ref 543468(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).
Ref 543468(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).

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