Drug Information

Drug General Information
Drug ID
D03UZP
Former ID
DIB000661
Drug Name
RG7888
Synonyms
MOXR0916
Drug Type
Antibody
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [525142]
Target and Pathway
Target(s) OX40 ligand Target Info [544456]
KEGG Pathway Cytokine-cytokine receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TSLP Signaling Pathway
Reactome TNFs bind their physiological receptors
WikiPathways Vitamin D Receptor Pathway
TSLP Signaling Pathway
References
Ref 525142ClinicalTrials.gov (NCT02410512) A Dose-Escalation Study of the Safety and Pharmacokinetics of MOXR0916 and MPDL3280A in Patients With Locally Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health.
Ref 544456Anti-tumor efficacy and biomarker evaluation of agonistic anti-OX40 antibodies in preclinical models. J Immunother Cancer. 2014; 2(Suppl 3): P105.

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