Drug Information

Drug General Information
Drug ID
D03YOS
Former ID
DCL000196
Drug Name
Phenoxodiol
Synonyms
Dehydroequol; Idronoxil; Haginin E; NV 06; NV-06; Idronoxil (USAN/INN); 2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl); 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol; 3-(4-Hydroxyphenyl)-2H-chromen-7-ol; 7-hydroxy-3-hydroxyphenyl-1H-benzopyran
Drug Type
Small molecular drug
Indication Late-stage ovarian cancer; Lymphoma [ICD9: 140-229, 183, 188, 202.8, 208.9; ICD10:C56, C67, C81-C86] Phase 1/2 [521895]
Therapeutic Class
Anticancer Agents
Company
Marshall Edwards
Structure
Download
2D MOL

3D MOL
Formula
C15H12O3
Canonical SMILES
C1C(=CC2=C(O1)C=C(C=C2)O)C3=CC=C(C=C3)O
InChI
1S/C15H12O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-8,16-17H,9H2
InChIKey
ZZUBHVMHNVYXRR-UHFFFAOYSA-N
CAS Number
CAS 81267-65-4
PubChem Compound ID
219100
PubChem Substance ID
3191506, 9374282, 15121904, 30422461, 47206346, 50066225, 52830969, 53789188, 57304385, 57399844, 68529941, 99299658, 113468599, 119525774, 126598392, 126684168, 134338864, 135142360, 136341474, 136929242, 137248187, 140343573, 152057424, 162248991, 162916982, 163368956, 164787401, 172912681, 174006673, 175426901, 176238356, 184603132, 186024306, 198937807, 221678827, 223509024, 223535513, 223682224, 223704958, 224588223, 226515077, 243323551, 249727332, 249780348, 252303380
Target and Pathway
Target(s) X-linked inhibitor of apoptosis protein Target Info Modulator [1572591]
Sphingosine kinase Target Info Modulator [1572591]
BioCyc Pathway Sphingosine and sphingosine-1-phosphate metabolism
KEGG Pathway NF-kappa B signaling pathway
Ubiquitin mediated proteolysis
Apoptosis
Focal adhesion
Toxoplasmosis
HTLV-I infection
Pathways in cancer
Small cell lung cancerhsa00600:Sphingolipid metabolism
Metabolic pathways
Calcium signaling pathway
Sphingolipid signaling pathway
VEGF signaling pathway
Fc gamma R-mediated phagocytosis
Tuberculosis
NetPath Pathway TCR Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Apoptosis signaling pathwayP00005:Angiogenesis
VEGF signaling pathway
Pathway Interaction Database p75(NTR)-mediated signaling
BMP receptor signaling
Caspase Cascade in Apoptosis
TGF-beta receptor signalingfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Beta3 integrin cell surface interactions
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Deactivation of the beta-catenin transactivating complex
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell deathR-HSA-1660661:Sphingolipid de novo biosynthesis
VEGFR2 mediated cell proliferation
WikiPathways Copper homeostasis
Focal Adhesion
Apoptosis
Intrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
NOD pathwayWP26:Signal Transduction of S1P Receptor
Protein folding
Sphingolipid Metabolism
References
Ref 521895ClinicalTrials.gov (NCT00382811) OVATURE (OVArian TUmor REsponse) A Phase III Study of Weekly Carboplatin With and Without Phenoxodiol in Patients With Platinum-Resistant, Recurrent Epithelial Ovarian Cancer. U.S. National Institutes of Health.
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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