Drug Information

Drug General Information
Drug ID
D03YSQ
Former ID
DIB002233
Drug Name
SAR-405838
Synonyms
AT-219; MI-147; MI-219; MI-319; MI-43; MI-5; MI-63; MI-772; MI-773; MI-519-64; P53-HDM2 protein interaction inhibitors (cancer); P53-HDM2 protein interaction inhibitors (cancer), Ascenta/Sanofi; P53-HDM2 protein interaction inhibitors (cancer), Ascenta/sanofi-aventis
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [549401]
Company
Ascenta Therapeutics; Sanofi US
Structure
Download
2D MOL

3D MOL
Formula
C29H35Cl2FN4O3
Canonical SMILES
CC(C)(C)CC1C2(C(C(N1)C(=O)NCCN3CCOCC3)C4=C(C(=CC=C4)Cl)<br />F)C5=C(C=C(C=C5)Cl)NC2=O
InChI
1S/C29H35Cl2FN4O3/c1-28(2,3)16-22-29(19-8-7-17(30)15-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-9-10-36-11-13-39-14-12-36/h4-8,15,22-23,25,35H,9-14,16H2,1-3H3,(H,33,37)(H,34,38)/t22-,23+,25-,29+/m1/s1
InChIKey
YTBYOWZWBDYLQF-BGLPIVGWSA-N
PubChem Compound ID
11512578
PubChem Substance ID
16614436, 23641809, 49684269, 50132897, 80662834, 85163803, 103489256, 140906067, 228840288, 248964827
Target and Pathway
Target(s) Cellular tumor antigenp53 Target Info Modulator [532926]
KEGG Pathway MAPK signaling pathway
Sphingolipid signaling pathway
Cell cycle
p53 signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Wnt signaling pathway
Neurotrophin signaling pathway
Thyroid hormone signaling pathway
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Hepatitis C
Hepatitis B
Measles
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Basal cell carcinoma
Melanoma
Bladder cancer
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Huntington disease
Wnt signaling pathway
p53 pathway
P53 pathway feedback loops 1
p53 pathway by glucose deprivation
p53 pathway feedback loops 2
Pathway Interaction Database Signaling events mediated by HDAC Class III
Validated targets of C-MYC transcriptional activation
LKB1 signaling events
Glucocorticoid receptor regulatory network
Direct p53 effectors
p75(NTR)-mediated signaling
AP-1 transcription factor network
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Signaling mediated by p38-alpha and p38-beta
Aurora A signaling
BARD1 signaling events
p53 pathway
PLK3 signaling events
Reactome Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
DNA Damage/Telomere Stress Induced Senescence
Autodegradation of the E3 ubiquitin ligase COP1
TP53 Regulates Metabolic Genes
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Stabilization of p53
Factors involved in megakaryocyte development and platelet production
WikiPathways DNA Damage Response (only ATM dependent)
DNA Damage Response
ErbB Signaling Pathway
Senescence and Autophagy in Cancer
G1 to S cell cycle control
Sandbox Pathway
Wnt Signaling Pathway and Pluripotency
MAPK Signaling Pathway
TGF beta Signaling Pathway
Copper homeostasis
Bladder Cancer
Mammary gland development pathway - Involution (Stage 4 of 4)
Pre-NOTCH Expression and Processing
Apoptosis
ATM Signaling Pathway
Amyotrophic lateral sclerosis (ALS)
Retinoblastoma (RB) in Cancer
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Gastric cancer network 2
Prostate Cancer
Signaling Pathways in Glioblastoma
Metastatic brain tumor
Alzheimers Disease
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Intrinsic Pathway for Apoptosis
Factors involved in megakaryocyte development and platelet production
Cell Cycle
Cell Cycle Checkpoints
Apoptosis Modulation and Signaling
Folate Metabolism
TP53 Network
Fluoropyrimidine Activity
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
AMPK Signaling
References
Ref 549401Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036509)
Ref 532926SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res. 2014 Oct 15;74(20):5855-65.

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