Drug Information

Drug General Information
Drug ID
D04EDQ
Former ID
DIB013683
Drug Name
CXCR3 antagonists
Synonyms
CXCR3 antagonists (rheumatoid arthritis); CXCR3 antagonists (rheumatoid arthritis), Merck Serono
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Investigative [552070]
Company
Merck Serono SA
Structure
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2D MOL

3D MOL
Canonical SMILES
n1nn[nH]c1c1c(cc(CN(S(=O)(=O)c2ccc(cc2)C#N)Cc2c(cccc2)F<br />)cc1)F
Target and Pathway
Target(s) C-X-C chemokine receptor type 3 Target Info Antagonist [543922]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database CXCR3-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 552070Discovery of a novel series of CXCR3 antagonists. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3614-7
Ref 543922(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 70).

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