Drug Information

Drug General Information
Drug ID
D04NIZ
Former ID
DNCL003081
Drug Name
AMG 747
Indication Schizophrenia [ICD9: 295; ICD10:F20] Phase 2 [523858]
Company
Amgen
Target and Pathway
Target(s) Sodium- and chloride-dependent glycine transporter 1 Target Info Modulator [532527]
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways NRF2 pathway
References
Ref 523858ClinicalTrials.gov (NCT01568216) 20101299: Study to Evaluate the Effect of AMG 747 on Schizophrenia Negative Symptoms. U.S. National Institutes of Health.
Ref 532527Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. Nat Rev Drug Discov. 2013 Nov;12(11):866-85.

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