TTD | Drug: D04QAE

Drug General Information
Drug ID	D04QAE
Former ID	DIB012132
Drug Name	CXCR3 antagonists
Synonyms	CXCR3 antagonists (autoimmune disease); CXCR3 antagonists (autoimmune disease), Amgen
Indication	Autoimmune diabetes [ICD10:E08-E13]		Investigative	[552115]
Company	Amgen Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	O=S1(=O)CCC(CN([C@@H](c2nc3ncccc3c(=O)n2c2ccc(cc2)Cl)C)<br />C(=O)Cc2ccc(C(F)(F)F)c(c2)F)CC1
Target and Pathway
Target(s)	C-X-C chemokine receptor type 3	Target Info	Antagonist	[543922]
KEGG Pathway	Cytokine-cytokine receptor interaction
KEGG Pathway	Chemokine signaling pathway
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database	CXCR3-mediated signaling events
Reactome	Chemokine receptors bind chemokines
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 552115	Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme. Drug Metab Dispos. 2012 Jul;40(7):1429-40
Ref 543922	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 70).

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Drug Information