Drug Information

Drug General Information
Drug ID
D04VPH
Former ID
DIB019249
Drug Name
compound 15
Synonyms
4UF
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531667], [543223]
Structure
Download
2D MOL
Formula
C24H22N4O5
InChI
InChI=1S/C24H22N4O5/c1-3-33-24(32)20-11-17-10-16(8-9-18(17)26-20)21-12-19(27-28(21)2)22(29)25-13-14-4-6-15(7-5-14)23(30)31/h4-12,26H,3,13H2,1-2H3,(H,25,29)(H,30,31)
InChIKey
MMJPVSDTLGFIQW-UHFFFAOYSA-N
PubChem Compound ID
45376872
PubChem Substance ID
93368379, 120288851, 136929043, 136965680, 227537965, 242799207, 251973293, 252166836
Target and Pathway
Target(s) Collagenase 3 Target Info Inhibitor [531667]
NetPath Pathway IL1 Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
WikiPathways Endochondral Ossification
Activation of Matrix Metalloproteinases
Oncostatin M Signaling Pathway
AGE/RAGE pathway
Matrix Metalloproteinases
References
Ref 531667Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J Med Chem. 2011 Dec 8;54(23):8174-87.
Ref 543223(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8636).
Ref 531667Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J Med Chem. 2011 Dec 8;54(23):8174-87.

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