Drug General Information
Drug ID	D05GMV
Former ID	DPR000108
Drug Name	SMP-534
Drug Type	Small molecular drug
Indication	Diabetic nephropathy [ICD9: 250.4; ICD10:E11.21]		Preclinical	[536836]
Company	Dainippon Sumitomo Pharma
Structure		Download 2D MOL 3D MOL
Formula	C11H14O2S
Canonical SMILES	CC1=C(SC(C1=O)(C)C=C(C)C=C)O
InChI	1S/C11H14O2S/c1-5-7(2)6-11(4)9(12)8(3)10(13)14-11/h5-6,13H,1H2,2-4H3/b7-6+/t11-/m1/s1
InChIKey	HGCGJTZCWZFGBT-XUIVZRPNSA-N
PubChem Compound ID	445629
PubChem Substance ID	13347, 621341, 819775, 7890788, 12015257, 16288707, 17405466, 24278631, 32964498, 36888281, 46391893, 46491024, 46505720, 48169378, 50054156, 50106765, 50106766, 52110779, 53778014, 53813060, 57391946, 57404693, 84975004, 92304107, 103551068, 104065270, 104634710, 121361562, 124750089, 134338703, 134339547, 134340616, 135030651, 137245183, 140421192, 160967345, 163564862, 164187185, 179678465, 184534105, 208013918, 237212483, 238329620, 241163324
Target and Pathway
Target(s)	MAP kinase p38	Target Info	Inhibitor	[536836]
KEGG Pathway	MAPK signaling pathway
	Rap1 signaling pathway
	FoxO signaling pathway
	Sphingolipid signaling pathway
	Oocyte meiosis
	Adrenergic signaling in cardiomyocytes
	VEGF signaling pathway
	Osteoclast differentiation
	Signaling pathways regulating pluripotency of stem cells
	Platelet activation
	Toll-like receptor signaling pathway
	NOD-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	T cell receptor signaling pathway
	Fc epsilon RI signaling pathway
	TNF signaling pathway
	Leukocyte transendothelial migration
	Neurotrophin signaling pathway
	Retrograde endocannabinoid signaling
	Dopaminergic synapse
	Inflammatory mediator regulation of TRP channels
	GnRH signaling pathway
	Progesterone-mediated oocyte maturation
	Prolactin signaling pathway
	Amyotrophic lateral sclerosis (ALS)
	Epithelial cell signaling in Helicobacter pylori infection
	Shigellosis
	Salmonella infection
	Pertussis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Tuberculosis
	Hepatitis C
	Influenza A
	Epstein-Barr virus infection
	Proteoglycans in cancer
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	B cell activation
	EGF receptor signaling pathway
	FGF signaling pathway
	Interferon-gamma signaling pathway
	Oxidative stress response
	Parkinson disease
	TGF-beta signaling pathway
	Ras Pathway
	p53 pathway feedback loops 2
	p38 MAPK pathway
Pathway Interaction Database	RhoA signaling pathway
	Signaling mediated by p38-gamma and p38-delta
Reactome	NOD1/2 Signaling Pathway
	p38MAPK events
	Activation of PPARGC1A (PGC-1alpha) by phosphorylation
	CDO in myogenesis
	DSCAM interactions
	VEGFA-VEGFR2 Pathway
WikiPathways	Toll-like receptor signaling pathway
	Insulin Signaling
	MAPK Cascade
	MAPK Signaling Pathway
	Nanoparticle-mediated activation of receptor signaling
	Signal Transduction of S1P Receptor
	Parkinsons Disease Pathway
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	NGF signalling via TRKA from the plasma membrane
	Myogenesis
	Integrin-mediated Cell Adhesion
	DSCAM interactions
	Regulation of toll-like receptor signaling pathway
References
Ref 536836	Agents in development for the treatment of diabetic nephropathy. Expert Opin Emerg Drugs. 2008 Sep;13(3):447-63.
Ref 536836	Agents in development for the treatment of diabetic nephropathy. Expert Opin Emerg Drugs. 2008 Sep;13(3):447-63.

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