Drug Information

Drug General Information
Drug ID
D05GSZ
Former ID
DNC003604
Drug Name
AR-HO29953XX
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527611]
Structure
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2D MOL

3D MOL
Formula
C21H15Cl2N3O5
Canonical SMILES
C1=CC(=CC=C1CNC2=C(C=CC(=C2)[N+](=O)[O-])C(=O)O)C(=O)NC<br />3=CC(=C(C=C3)Cl)Cl
InChI
1S/C21H15Cl2N3O5/c22-17-8-5-14(9-18(17)23)25-20(27)13-3-1-12(2-4-13)11-24-19-10-15(26(30)31)6-7-16(19)21(28)29/h1-10,24H,11H2,(H,25,27)(H,28,29)
InChIKey
HMZYRLHWICHTKH-UHFFFAOYSA-N
PubChem Compound ID
10479348
Target and Pathway
Target(s) Plasminogen activator inhibitor-1 Target Info Inhibitor [527611]
KEGG Pathway HIF-1 signaling pathway
p53 signaling pathway
Hippo signaling pathway
Complement and coagulation cascades
Chagas disease (American trypanosomiasis)
NetPath Pathway TWEAK Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Blood coagulation
Plasminogen activating cascade
p53 pathway
CCKR signaling map ST
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
p73 transcription factor network
E2F transcription factor network
HIF-2-alpha transcription factor network
Direct p53 effectors
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
HIF-1-alpha transcription factor network
Reactome Platelet degranulation
BMAL1:CLOCK,NPAS2 activates circadian gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
ECM proteoglycans
Dissolution of Fibrin Clot
WikiPathways Senescence and Autophagy in Cancer
TGF Beta Signaling Pathway
Complement and Coagulation Cascades
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Blood Clotting Cascade
Extracellular matrix organization
Oncostatin M Signaling Pathway
Adipogenesis
Dissolution of Fibrin Clot
Circadian Clock
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 527611Bioorg Med Chem Lett. 2005 Aug 1;15(15):3514-8.Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1.
Ref 527611Bioorg Med Chem Lett. 2005 Aug 1;15(15):3514-8.Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1.

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