Drug Information

Drug General Information
Drug ID
D05SLY
Former ID
DIB020950
Drug Name
SK1-I
Synonyms
BML-258
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541732]
Structure
Download
2D MOL
Formula
C17H27NO2
InChI
InChI=1S/C17H27NO2/c1-3-4-5-6-14-7-9-15(10-8-14)11-12-17(20)16(13-19)18-2/h7-12,16-20H,3-6,13H2,1-2H3/b12-11+/t16-,17+/m1/s1
InChIKey
JYEXUQKROPHSEF-SFDDJJRUSA-N
PubChem Compound ID
44815217
PubChem Substance ID
87547945, 89443710, 120131224, 140530987, 141253149, 174506005, 178103235, 194941285, 226492460, 239610365
Target and Pathway
Target(s) Sphingosine kinase Target Info Inhibitor [529501]
BioCyc Pathway Sphingosine and sphingosine-1-phosphate metabolism
KEGG Pathway Sphingolipid metabolism
Metabolic pathways
Calcium signaling pathway
Sphingolipid signaling pathway
VEGF signaling pathway
Fc gamma R-mediated phagocytosis
Tuberculosis
NetPath Pathway TCR Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
Beta3 integrin cell surface interactions
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome Sphingolipid de novo biosynthesis
VEGFR2 mediated cell proliferation
WikiPathways Signal Transduction of S1P Receptor
Protein folding
Sphingolipid Metabolism
References
Ref 541732(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6622).
Ref 529501A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood. 2008 Aug 15;112(4):1382-91.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.