Drug Information

Drug General Information
Drug ID
D05WWJ
Former ID
DCL000690
Drug Name
ALX-5407
Synonyms
NFPS; ALX5407; 2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid; 2-[[3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Phase 1 [467857], [536463]
Company
NPS Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C24H24FNO3
InChI
InChI=1S/C24H24FNO3/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18/h2-14,23H,15-17H2,1H3,(H,27,28)/t23-/m1/s1
InChIKey
FDORQEIHOKEJNX-HSZRJFAPSA-N
CAS Number
CAS 571147-18-7
PubChem Compound ID
6604909
PubChem Substance ID
11114199, 11646540, 15401349, 43224645, 57304382, 78757041, 85787628, 103448993, 104037946, 114638213, 142331529, 178101336, 227301197, 244069016, 251962955
Target and Pathway
Target(s) Sodium- and chloride-dependent glycine transporter 1 Target Info Blocker [526208], [536463]
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways NRF2 pathway
References
Ref 467857(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4618).
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 526208Mol Pharmacol. 2001 Dec;60(6):1414-20.ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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