Drug General Information
Drug ID	D05ZDJ
Former ID	DIB008167
Drug Name	THR-18
Indication	Asthma [ICD10:J45]		Phase 2	[525337]
Company	Thrombotech Technologies Ltd
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Plasminogen activator inhibitor-1	Target Info	Activator	[531696]
KEGG Pathway	HIF-1 signaling pathway
	p53 signaling pathway
	Hippo signaling pathway
	Complement and coagulation cascades
	Chagas disease (American trypanosomiasis)
NetPath Pathway	TWEAK Signaling Pathway
	IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Blood coagulation
	Plasminogen activating cascade
	p53 pathway
	CCKR signaling map ST
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	p73 transcription factor network
	E2F transcription factor network
	HIF-2-alpha transcription factor network
	Direct p53 effectors
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	HIF-1-alpha transcription factor network
Reactome	Platelet degranulation
	BMAL1:CLOCK,NPAS2 activates circadian gene expression
	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
	ECM proteoglycans
	Dissolution of Fibrin Clot
WikiPathways	Senescence and Autophagy in Cancer
	TGF Beta Signaling Pathway
	Complement and Coagulation Cascades
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Blood Clotting Cascade
	Extracellular matrix organization
	Oncostatin M Signaling Pathway
	Adipogenesis
	Dissolution of Fibrin Clot
	Circadian Clock
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 525337	ClinicalTrials.gov (NCT02572336) A Study of the Safety, Imaging and Clinical Outcomes of THR-18 in Acute Stroke Subjects Treated With tPA.
Ref 531696	THR-18, a 18-mer peptide derived from PAI-1, is neuroprotective and improves thrombolysis by tPA in rat stroke models. Neurol Res. 2011 Nov;33(9):983-90.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.