Drug Information

Drug General Information
Drug ID
D06GZW
Former ID
DIB007447
Drug Name
PEGylated leptin
Synonyms
PEG-Leptin; PEGylated leptin (obesity/type 1 diabetes); PEGylated leptin (obesity/type 1 diabetes), Ambrx
Indication Obesity [ICD9: 278; ICD10:E66] Investigative [543464]
Company
Ambrx Inc
Target and Pathway
Target(s) Leptin receptor Target Info Modulator [543464]
KEGG Pathway Cytokine-cytokine receptor interaction
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Jak-STAT signaling pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Pathway Interaction Database Signaling events mediated by PTP1B
WikiPathways Leptin signaling pathway
AMPK Signaling
References
Ref 543464(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712).
Ref 543464(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712).

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