Drug Information

Drug General Information
Drug ID
D07EBF
Former ID
DNCL001597
Drug Name
CK-2017357
Drug Type
Small molecular drug
Indication Muscle fatigue [ICD9: 780.7; ICD10:R53] Phase 2 [523056], [543035]
Company
Cytokinetics
Structure
Download
2D MOL

3D MOL
Formula
C12H14N4O
InChI
InChI=1S/C12H14N4O/c1-4-8-7-13-10-11(14-8)16(12(17)15-10)9(5-2)6-3/h1,7,9H,5-6H2,2-3H3,(H,13,15,17)
InChIKey
RSQGZEAXODVTOL-UHFFFAOYSA-N
PubChem Compound ID
23729157
PubChem Substance ID
47213940, 49814411, 56056035, 137874443, 162108795, 163312357, 174505061, 198934685, 210275455, 210281103, 223366689, 224185751, 227234414, 242060057, 247831743, 251962677, 252166492, 252448940, 252451781
Target and Pathway
Target(s) Fast skeletal muscle troponin complex Target Info Modulator [531804], [532793]
PathWhiz Pathway Muscle/Heart Contraction
Reactome Striated Muscle Contraction
WikiPathways Striated Muscle Contraction
Muscle contraction
References
Ref 523056ClinicalTrials.gov (NCT01131013) A Study of CK-2017357 in Patients With Peripheral Artery Disease and Symptomatic Claudication. U.S. National Institutes of Health.
Ref 543035(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8280).
Ref 531804Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5.
Ref 532793Effect of tirasemtiv, a selective activator of the fast skeletal muscle troponin complex, in patients with peripheral artery disease. Vasc Med. 2014 May 28;19(4):297-306.

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