Drug Information

Drug General Information
Drug ID
D08ENB
Former ID
DIB015662
Drug Name
GSK1995057
Drug Type
Antibody
Indication Adult respiratory distress syndrome [ICD9: 518.5, 518.82; ICD10:J80] Phase 1 [523888]
Company
Quark Pharmaceuticals
Target and Pathway
Target(s) Tumour necrosis factor receptor-1 (TNFR1) Target Info [532420]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Sphingolipid signaling pathway
Apoptosis
Osteoclast differentiation
TNF signaling pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Influenza A
HTLV-I infection
Herpes simplex infection
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Pathway Interaction Database Canonical NF-kappaB pathway
Signaling events mediated by HDAC Class I
TNF receptor signaling pathway
Ceramide signaling pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Reactome TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFs bind their physiological receptors
TNF signaling
WikiPathways Inflammatory Response Pathway
Apoptosis Modulation by HSP70
Cardiac Hypertrophic Response
Apoptosis
Nanoparticle triggered regulated necrosis
Amyotrophic lateral sclerosis (ALS)
Integrated Pancreatic Cancer Pathway
TNF alpha Signaling Pathway
Alzheimers Disease
Extrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
References
Ref 523888ClinicalTrials.gov (NCT01587807) A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of Inhaled GSK1995057. U.S. National Institutes of Health.
Ref 532420Autoantibodies to variable heavy (VH) chain Ig sequences in humans impact the safety and clinical pharmacology of a VH domain antibody antagonist of TNF-alpha receptor 1. J Clin Immunol. 2013 Oct;33(7):1192-203.

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