Drug Information

Drug General Information
Drug ID
D08JRT
Former ID
DCL000621
Drug Name
RhApo2L/TRAIL
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Discontinued in Phase 1/2 [546989]
Company
Amgen
Target and Pathway
Target(s) Tumor necrosis factor receptor superfamily member 10A Target Info Agonist [525341], [550250]
Tumor necrosis factor receptor superfamily member 10B Target Info Agonist [525341], [550250]
KEGG Pathway Cytokine-cytokine receptor interaction
Apoptosis
Natural killer cell mediated cytotoxicity
Measles
Influenza Ahsa04060:Cytokine-cytokine receptor interaction
p53 signaling pathway
Influenza A
NetPath Pathway TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
p53 pathwayP00006:Apoptosis signaling pathway
p53 pathway
Pathway Interaction Database TRAIL signaling pathway
Direct p53 effectors
Caspase Cascade in Apoptosistrail_pathway:TRAIL signaling pathway
Caspase Cascade in Apoptosis
Reactome Ligand-dependent caspase activation
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signalingR-HSA-140534:Ligand-dependent caspase activation
TRAIL signaling
WikiPathways miR-targeted genes in lymphocytes - TarBase
Apoptosis Modulation and SignalingWP707:DNA Damage Response
Apoptosis-related network due to altered Notch3 in ovarian cancer
Apoptosis
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in epithelium - TarBase
Extrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
miRNA Regulation of DNA Damage Response
References
Ref 546989Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011860)
Ref 525341ClinicalTrials.gov (NCT00508625) Amgen. Report of Amgen. July 2007.
Ref 550250Clinical pipeline report, company report or official report of Amgen (2009).

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