Drug General Information
Drug ID	D08OOJ
Former ID	DIB011312
Drug Name	CB-5083
Indication	Multiple myeloma [ICD9: 203; ICD10:C90]		Phase 1	[524919]
Company	Cleave biosciences
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Valosin-containing protein p97	Target Info	Inhibitor	[544482]
KEGG Pathway	Protein processing in endoplasmic reticulum
	Legionellosis
Reactome	Hedgehog ligand biogenesis
	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
References
Ref 524919	ClinicalTrials.gov (NCT02243917) A Phase 1 Study Evaluating CB-5083 in Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
Ref 544482	Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC Cancer. 2015; 15: 479.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.