Drug Information

Drug General Information
Drug ID
D08PKG
Former ID
DNCL001627
Drug Name
LY2541546
Synonyms
LY2541546
Drug Type
Antibody
Indication Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890] Phase 2 [523075]
Company
Eli Lilly
Target and Pathway
Target(s) Sclerostin Target Info [531711]
KEGG Pathway Wnt signaling pathway
NetPath Pathway TWEAK Signaling Pathway
Reactome TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
References
Ref 523075ClinicalTrials.gov (NCT01144377) A Study of LY2541546 in Women With Low Bone Mineral Density. U.S. National Institutes of Health.
Ref 531711Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin. Toxicol Sci. 2012 Feb;125(2):586-94.

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