Drug Information

Drug General Information
Drug ID
D08SND
Former ID
DIB020683
Drug Name
PF-543
Synonyms
sphingosine kinase 1 Inhibitor II; PF 543
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541733]
Structure
Download
2D MOL
Formula
C27H31NO4S
InChI
InChI=1S/C27H31NO4S/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29/h2-4,7-12,14-16,25,29H,5-6,13,17-20H2,1H3/t25-/m1/s1
InChIKey
NPUXORBZRBIOMQ-RUZDIDTESA-N
PubChem Compound ID
66577038
PubChem Substance ID
152258716, 160647551, 172088858, 177749157, 178103236, 185966797, 190861994, 194168492, 211786848, 252552915
Target and Pathway
Target(s) Sphingosine kinase Target Info Inhibitor [531834]
BioCyc Pathway Sphingosine and sphingosine-1-phosphate metabolism
KEGG Pathway Sphingolipid metabolism
Metabolic pathways
Calcium signaling pathway
Sphingolipid signaling pathway
VEGF signaling pathway
Fc gamma R-mediated phagocytosis
Tuberculosis
NetPath Pathway TCR Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
Beta3 integrin cell surface interactions
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome Sphingolipid de novo biosynthesis
VEGFR2 mediated cell proliferation
WikiPathways Signal Transduction of S1P Receptor
Protein folding
Sphingolipid Metabolism
References
Ref 541733(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6623).
Ref 531834Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88.

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