Drug General Information
Drug ID
D08UZL
Former ID
DNC001452
Drug Name
TMPyP4
Drug Type
Small molecular drug
Indication Multiple myeloma [ICD9: 203; ICD10:C90] Investigative [537114]
Company
Geron Corp
Structure
Download
2D MOL

3D MOL

Formula
C44H38N8+4
Canonical SMILES
C[N+]1=CC=C(C=C1)C2=C3C=CC(=C(C4=CC=C(N4)C(=C5C=CC(=N5)<br />C(=C6C=CC2=N6)C7=CC=[N+](C=C7)C)C8=CC=[N+](C=C8)C)C9=CC<br />=[N+](C=C9)C)N3
InChI
1S/C44H37N8/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31/h5-28H,1-4H3,(H,45,46,47,48)/q+3/p+1
InChIKey
ABCGFHPGHXSVKI-UHFFFAOYSA-O
CAS Number
CAS 36951-72-1
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Telomerase reverse transcriptase Target Info Inhibitor [537114]
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
Regulation of Telomerase
IL2 signaling events mediated by PI3K
Regulation of nuclear beta catenin signaling and target gene transcription
HIF-1-alpha transcription factor network
Reactome Formation of the beta-catenin:TCF transactivating complex
References
Ref 537114Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
Ref 537114Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.

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