Drug Information

Drug General Information
Drug ID
D08WSY
Former ID
DCL000516
Drug Name
Denosumab
Synonyms
Denosumab (USAN); Denosumab (genetical recombination); Prolia (TN); Denosumab (genetical recombination) (JAN)
Drug Type
Antibody
Indication Postmenopausal osteoporosis [ICD9: 733; ICD10:M80-M81] Approved [531351], [541943]
Bone metastases in prostate cancer [ICD9: 185, 198.5; ICD10:C61, C79.51] Phase 3 [531351], [541943]
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 2 [531351], [541943]
Company
Amgen
CAS Number
CAS 615258-40-7
PubChem Substance ID
17397780
SuperDrug ATC ID
M05BX04
Target and Pathway
Target(s) Tumor necrosis factor ligand superfamily member 11 Target Info [531351]
KEGG Pathway Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Osteoclast differentiation
Prolactin signaling pathway
Rheumatoid arthritis
NetPath Pathway Leptin Signaling Pathway
TWEAK Signaling Pathway
Pathway Interaction Database IL6-mediated signaling events
Reactome TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
WikiPathways Osteoblast Signaling
Vitamin D Receptor Pathway
Differentiation Pathway
RANKL/RANK Signaling Pathway
Osteoclast Signaling
References
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 541943(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6886).
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.

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