Drug Information

Drug General Information
Drug ID
D09ENR
Former ID
DIB007945
Drug Name
Itarnafloxin
Synonyms
Quarfloxin; CX-3385; CX-3543; Quadruplex DNA oncogene inhibitor (cancer), Cylene; C-Myc/VEGF oncogene inhibitor (cancer), Cylene
Drug Type
Small molecular drug
Indication Leukemia [ICD9: 208.9; ICD10:C90-C95] Phase 2 [544179]
Company
Cylene Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C35H33FN6O3
Canonical SMILES
n1ccnc(c1)C1CN(CC1)c1c(cc2c(=O)c(cn3c2c1oc1c3cc2c(c1)cc<br />cc2)C(=O)NCC[C@@H]1CCCN1C)F
CAS Number
CAS 865311-47-3
PubChem Compound ID
44148637
Target and Pathway
Target(s) Nucleolin Target Info Inhibitor [544179]
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Aurora B signaling
Validated targets of C-MYC transcriptional activation
Regulation of Telomerase
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
WikiPathways Pathogenic Escherichia coli infection
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 544179Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?. Nat Rev Drug Discov. 2011 April; 10(4): 261-275.
Ref 544179Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?. Nat Rev Drug Discov. 2011 April; 10(4): 261-275.

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